Restoring Cervical Lymphatic Drainage in Alzheimer's Disease

NCT ID
NCT07854327
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
University of Siena
Conditions
Alzheimer, Alzheimer Dementia (AD)

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Evaluating the Effects of Restoring Lymphatic Drainage in Alzheimer's Disease: The LymphDAD Pilot Study

Enrollment: 5 participants (Estimated).

What is being studied

  • Procedure: Cervical lymphovenous anastomosis (LVA)

Who may be eligible

Ages
Not specified in the registry data
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Diagnosis of Alzheimer's disease according to NIA-AA 2024 criteria. * Not eligible for other disease-modifying therapies. * Ability to personally provide written informed consent after clinical evaluation -of decisional capacity. Exclusion Criteria: * Coagulopathy or active infection of the head and neck region. * Prior extensive cervical lymph node dissection or radiotherapy. * Uncontrolled systemic disease or contraindication to general anesthesia. * Participation in another interventional trial within the previous 3 months. * Known hypersensitivity or allergy to indocyanine green. * Evidence of alternative or concomitant causes of cognitive decline other than Alzheimer's disease, such as subdural hematoma, primary or metastatic brain malignancy, or normal-pressure hydrocephalus. * Current or recent treatment with immunosuppressive or immunomodulatory therapy within the previous 3 months. * Clinically significant infectious disease within the previous 6 months. * Severe psychiatric disorder that could interfere with cognitive assessment or study participation. * Pregnancy or breastfeeding. * End-stage malignant disease with an estimated life expectancy of less than 6 months. * History indicative of systemic autoimmune disease. * Inability to personally provide valid informed consent.

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: Italy

  • Tuscany, Italy: 1

Sample of listed locations

  • Azienda Ospedaliera Universitaria Le Scotte — Siena, Tuscany, 53100, Italy — Recruiting

Study details

Start date
July 1, 2026
Primary completion date
July 1, 2028
Completion date
December 31, 2028
First posted
October 2, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07854327
Registry last updated
October 2, 2026
QualifiedStudies registry data refreshed
October 12, 2026
QualifiedStudies record fetched
October 12, 2026

View NCT07854327 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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