Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty

NCT ID
NCT07853885
Registry status
Not yet recruiting
Study type
Interventional
Phase
Phase 4
Sponsor
The Second Affiliated Hospital of Kunming Medical University
Conditions
Knee Osteoarthritis

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Official title: Efficacy and Safety of Local Intraosseous Tranexamic Acid Injection for Reducing Perioperative Blood Loss in Total Knee Arthroplasty: A Randomized, Double-Blind, Controlled Trial

Enrollment: 70 participants (Estimated).

What is being studied

  • Intervention: Acids, Carbocyclic
  • Intervention: Carboxylic Acids
  • Intervention: Crystalloid Solutions
  • Intervention: Cyclohexanecarboxylic Acids
  • Intervention: Isotonic Solutions
  • Drug: Normal Saline
  • Intervention: Organic Chemicals
  • Intervention: Pharmaceutical Preparations
  • Intervention: Saline Solution
  • Intervention: Solutions
  • Drug: Tranexamic Acid
  • Intervention: Tranexamic Acid

Who may be eligible

Ages
50 Years to 85 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Age 50 to 85 years. * Diagnosis of primary knee osteoarthritis. * Scheduled to undergo primary unilateral total knee arthroplasty. * American Society of Anesthesiologists (ASA) physical status classification I to III. * Willing to participate in the study and able to provide written informed consent. Exclusion Criteria: * Known allergy or hypersensitivity to tranexamic acid. * History of thromboembolic disease, including deep vein thrombosis or pulmonary embolism. * Known hypercoagulable state or current use of anticoagulant therapy, except for protocol-permitted perioperative anticoagulation * Severe cardiac, hepatic, or renal dysfunction. * History of vascular stent implantation or peripheral vascular disease. * Active infection or previous surgery on the study knee. * Abnormal coagulation function, including an international normalized ratio (INR) greater than 1.5. * Pregnancy or breastfeeding.

Study locations

1 study location is listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: China

  • Yunnan, China: 1

Sample of listed locations

  • The Second Affiliated Hospital of Kunming Medical University — Kunming, Yunnan, 650000, China — Site recruitment status not specified in the registry data

Study details

Start date
October 1, 2026
Primary completion date
April 1, 2027
Completion date
July 1, 2027
First posted
October 2, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07853885
Registry last updated
October 2, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT07853885 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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