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A Study of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease (AD)

NCT ID: NCT07843459
Registry status: Not yet recruiting
Study type: Interventional
Phase: Phase 1
Sponsor: Eli Lilly and Company
Conditions: Alzheimer Disease, Amyloid, Healthy Volunteers, Plaque, Amyloid, Plasma

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Official title: A Placebo-Controlled, Single- and Multiple-Ascending Dose, Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease

Enrollment: 111 participants (Estimated).

What is being studied

Intervention: 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
Other: Florbetaben F 18
Intervention: florbetapir
Other: Florbetapir F18
Drug: LY4560736
Drug: Placebo

Who may be eligible

Ages: 18 Years to 85 Years
Sex: All
Healthy volunteers accepted: Yes

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Participants must meet eligibility criteria in the A1D-MC-ATMP screening protocol before entry into the treatment study. * To qualify as a participant of first-generation Japanese origin, the participant, the participant's biological parents, and all the participant's biological grandparents must be of exclusive Japanese descent and born in Japan. * To qualify as Chinese for this study, all four of the participant's biological grandparents must be of exclusive Chinese descent and born in China. Exclusion Criteria: * Have a condition that predisposes the participant to an infection. * Have a current or recent acute, active infection. * Have active tuberculosis (TB), have or have had latent TB. * Are receiving therapeutic antibodies or expected to initiate treatment with therapeutic antibodies during the study.

Study locations

18 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: China, Japan, United States

California, United States: 3
Florida, United States: 8
Georgia, United States: 1
Michigan, United States: 1

Sample of listed locations

Xuanwu Hospital Capital Medical University — Beijing, 100053, China — Site recruitment status not specified in the registry data
Huashan Hospital, Fudan University — Minhang District, 201107, China — Site recruitment status not specified in the registry data
Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine — Shanghai, 200127, China — Site recruitment status not specified in the registry data
The University of Tokyo Hospital — Bunkyō City, 113-8655, Japan — Site recruitment status not specified in the registry data
National Center for Geriatrics and Gerontology — Ōbu, 4748511, Japan — Site recruitment status not specified in the registry data
CenExel ACT — Anaheim, California, 92801, United States — Site recruitment status not specified in the registry data
Irvine Clinical Research — Irvine, California, 92614, United States — Site recruitment status not specified in the registry data
Collaborative Neuroscience Network - CNS — Los Alamitos, California, 90720, United States — Site recruitment status not specified in the registry data
Fortrea Clinical Research Unit — Daytona Beach, Florida, 32117, United States — Site recruitment status not specified in the registry data
K2 Medical Research - The Villages — Lady Lake, Florida, 32159, United States — Site recruitment status not specified in the registry data
K2 Medical Research — Maitland, Florida, 32751, United States — Site recruitment status not specified in the registry data
Charter Research — Orlando, Florida, 32803, United States — Site recruitment status not specified in the registry data
Progressive Medical Research — Port Orange, Florida, 32127, United States — Site recruitment status not specified in the registry data
Alzheimer's Research and Treatment Center — Stuart, Florida, 34996, United States — Site recruitment status not specified in the registry data
K2 Medical Research - Tampa — Tampa, Florida, 33634, United States — Site recruitment status not specified in the registry data
Charter Research — The Villages, Florida, 32162-2698, United States — Site recruitment status not specified in the registry data
Accel Research Sites - NeuroStudies Clinical Research Unit — Decatur, Georgia, 30030, United States — Site recruitment status not specified in the registry data
QUEST Research Institute — Farmington Hills, Michigan, 48334, United States — Site recruitment status not specified in the registry data

Study details

Start date: October 1, 2026
Primary completion date: July 1, 2028
Completion date: July 1, 2028
First posted: September 28, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07843459
Registry last updated: October 8, 2026
QualifiedStudies registry data refreshed: October 12, 2026
QualifiedStudies record fetched: October 12, 2026

View NCT07843459 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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