Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee
- NCT ID
- NCT07832669
- Registry status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- Northeastern University
- Conditions
- Knee Osteoarthristis, Knee Pain Arthritis, Knee Pain Chronic
Overview
ClinicalTrials.gov lists this study as Not yet recruiting.
Enrollment: 50 participants (Estimated).
What is being studied
- Other: Paired Pulse Electrical Stimulation (ppES)
- Other: Peripheral Electrical Stimulation (PES)
Who may be eligible
- Ages
- 45 Years to no maximum
- Sex
- All
- Healthy volunteers accepted
- No
ClinicalTrials.gov lists the following eligibility criteria.
Inclusion Criteria:
* \>45 years old
* Able to speak and understand English
* Unilateral or bilateral knee OA, per NICE criteria
* Age 45+ AND
* Have activity-related joint pain AND
* Have either no morning joint-related stiffness or morning stiffness that lasts no longer than 30 minutes
* Score \> 3/20 on WOMAC pain scale
* If using pain medications, report \>4 weeks of stable use without recent adjustments
Exclusion Criteria:
* History of lower extremity surgery.
* BMI \> 40kg/m\^2
* Received an intra-articular knee joint injection within the last 3 months.
* Currently pregnant.
* Currently experiencing heavy menstruation, within one month of an IUD contraceptive device (e.g. coil) being fitted or within 6 weeks after giving birth or at least three months after having a Caesarean.
* Suspected or diagnosed heart problems (e.g. arrhythmia, cardiac disturbances).
* Use of an implanted electronic device (e.g. a cardiac pacemaker or defibrillator).
* Insulin-dependent diabetes.
* Implants in the lower limb.
* Suspected or diagnosed epilepsy or a familial history of epilepsy.
* History of neurologic or psychiatric condition (e.g. Parkinson's disease, bipolar disorder, epilepsy, etc)
* Implanted cardiac pacemaker, cochlear implant, medication pump, surgical clips or other metal (dental implants excluded).
* Use of alcohol or recreational drugs in the prior 12 hours.
* Frequent or severe headaches.
* Prior adverse reaction to transcranial magnetic stimulation.
* Altered sensation (hypo or hypersensitivity) of the skin of the thigh.
* Swollen, infected, inflamed, or damaged skin of the thigh.
* Current Use of prescription and over the counter medications will be grounds for exclusion except for:
* Contraceptive (birth control) drugs (e.g. those containing ethinyl estradiol and/or norethindrone).
* Seasonal allergy medications (e.g. cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin)).
* Antihypertensives
* Statins
* GLP-1 agonists
* Non-insulin diabetes medications (metformin)
* Thyroid medications
* Osteoporosis medications
* Respiratory medications
* Pain medications available over the counter (ibuprofen, acetaminophen, etc)
Study locations
No study locations are listed in the registry data.
Study details
- Start date
- September 1, 2026
- Primary completion date
- September 1, 2027
- Completion date
- September 1, 2027
- First posted
- September 22, 2026
Source and update information
- Source
- ClinicalTrials.gov
- NCT ID
- NCT07832669
- Registry last updated
- September 22, 2026
- QualifiedStudies registry data refreshed
- October 5, 2026
- QualifiedStudies record fetched
- October 5, 2026
View NCT07832669 on ClinicalTrials.gov
Trial information can change. Confirm current study details with the study team or the registry.
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