Stimulation of Peripheral Afferents to Reduce Muscle Inhibition at the Knee

NCT ID
NCT07832669
Registry status
Not yet recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Northeastern University
Conditions
Knee Osteoarthristis, Knee Pain Arthritis, Knee Pain Chronic

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Enrollment: 50 participants (Estimated).

What is being studied

  • Other: Paired Pulse Electrical Stimulation (ppES)
  • Other: Peripheral Electrical Stimulation (PES)

Who may be eligible

Ages
45 Years to no maximum
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * \>45 years old * Able to speak and understand English * Unilateral or bilateral knee OA, per NICE criteria * Age 45+ AND * Have activity-related joint pain AND * Have either no morning joint-related stiffness or morning stiffness that lasts no longer than 30 minutes * Score \> 3/20 on WOMAC pain scale * If using pain medications, report \>4 weeks of stable use without recent adjustments Exclusion Criteria: * History of lower extremity surgery. * BMI \> 40kg/m\^2 * Received an intra-articular knee joint injection within the last 3 months. * Currently pregnant. * Currently experiencing heavy menstruation, within one month of an IUD contraceptive device (e.g. coil) being fitted or within 6 weeks after giving birth or at least three months after having a Caesarean. * Suspected or diagnosed heart problems (e.g. arrhythmia, cardiac disturbances). * Use of an implanted electronic device (e.g. a cardiac pacemaker or defibrillator). * Insulin-dependent diabetes. * Implants in the lower limb. * Suspected or diagnosed epilepsy or a familial history of epilepsy. * History of neurologic or psychiatric condition (e.g. Parkinson's disease, bipolar disorder, epilepsy, etc) * Implanted cardiac pacemaker, cochlear implant, medication pump, surgical clips or other metal (dental implants excluded). * Use of alcohol or recreational drugs in the prior 12 hours. * Frequent or severe headaches. * Prior adverse reaction to transcranial magnetic stimulation. * Altered sensation (hypo or hypersensitivity) of the skin of the thigh. * Swollen, infected, inflamed, or damaged skin of the thigh. * Current Use of prescription and over the counter medications will be grounds for exclusion except for: * Contraceptive (birth control) drugs (e.g. those containing ethinyl estradiol and/or norethindrone). * Seasonal allergy medications (e.g. cetirizine (Zyrtec), fexofenadine (Allegra), and loratadine (Claritin)). * Antihypertensives * Statins * GLP-1 agonists * Non-insulin diabetes medications (metformin) * Thyroid medications * Osteoporosis medications * Respiratory medications * Pain medications available over the counter (ibuprofen, acetaminophen, etc)

Study locations

No study locations are listed in the registry data.

Study details

Start date
September 1, 2026
Primary completion date
September 1, 2027
Completion date
September 1, 2027
First posted
September 22, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07832669
Registry last updated
September 22, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT07832669 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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