Are clinical trials safe?

Yes. Every study on QualifiedStudies is reviewed and approved by an Institutional Review Board (IRB) and conducted under FDA regulations. Research sites are HIPAA-covered entities, and you can withdraw at any time for any reason.

Do I get paid to participate in a clinical trial?

Most studies offer compensation for your time and travel. The amount varies by study length and visit schedule, and is disclosed up front before you enroll.

Is my health information kept private?

Yes. Your information is encrypted, never sold, and only shared with the specific research site you choose to apply to. Our handling of your data is governed by our Consumer Health Data Privacy Policy; the research sites you're matched with are HIPAA-covered entities.

How do I qualify for a clinical trial?

Take our free 60-second eligibility quiz. Enter your ZIP code, condition, and a few health details, and we'll match you with research sites near you that are actively enrolling participants.

ACT4RHD is an Open-label, Randomised, Adaptive Platform Trial to Evaluate Novel and Repurposed Clinical Interventions for Patients With Acute Rheumatic Fever and Carditis. ACT4RHD Seeks to Determine Whether These Interventions Reduce RHD Severity at 6 Months.

NCT ID: NCT07830108
Registry status: Not yet recruiting
Study type: Interventional
Phase: Phase 3
Sponsor: Starship Child Health, Te Toka Tumai Auckland
Conditions: Acute Rheumatic Fever, Rheumatic Fever, Rheumatic Heart Disease, Rheumatic Heart Disease in Children

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Official title: ACT4RHD: Adaptive Collaborative Trial for Rheumatic Heart Disease

Enrollment: 600 participants (Estimated).

What is being studied

Intervention: Aminoquinolines
Intervention: Chloroquine
Intervention: Fused-Ring Compounds
Intervention: Heterocyclic Compounds
Intervention: Heterocyclic Compounds, 2-Ring
Intervention: Heterocyclic Compounds, Fused-Ring
Intervention: Hydroxychloroquine
Drug: Hydroxychloroquine (HCQ)
Other: No corticosteroid
Other: No Hydroxychloroquine (HCQ)
Intervention: Polycyclic Compounds
Intervention: Prednisolone
Intervention: Prednisone
Drug: Prednisone or Prednisolone
Intervention: Pregnadienediols
Intervention: Pregnadienes
Intervention: Pregnadienetriols
Intervention: Pregnanes
Intervention: Quinolines
Intervention: Steroids

Who may be eligible

Ages: 4 Years to 25 Years
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: 1. Aged ≥4 and ≤25 years old 2. Currently admitted to hospital, or hospital like setting, with the primary diagnosis of Definite or Possible Acute Rheumatic Fever (diagnosed according to the 2015 Jones Criteria) 3. Echocardiographic confirmed valvulitis during the current admission 4. If previous participation in the randomised ACT4RHD platform, then meets pre-specified criteria for re-enrolment 5. Patient expected to be able to complete protocol-required follow up assessments to 6 months post-enrolment Exclusion Criteria: 1. Presentation to current hospital was more than 10 days prior to randomisation 2. Cardiac surgery (or anticipated interhospital transfer for cardiac surgery) or death is anticipated within 72 hours from screening 3. Patient has had cardiac intervention (surgery or percutaneous) for RHD within the last 6 months 4. Previous cardiac intervention /surgery for RHD more than 6months ago, but patient has not had at least 2 post-intervention echocardiograms, including at least 1 echocardiogram more than 6months after the intervention. Each domain will have additional eligibility criteria. Refer to the appliable Domain Specific Appendix (DSA).

Study locations

3 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: Australia, New Zealand

Northern Territory, Australia: 1

Sample of listed locations

Royal Hospital — Darwin, Northern Territory, 0811, Australia — Site recruitment status not specified in the registry data
KidzFirst Hospital — Auckland, 2104, New Zealand — Site recruitment status not specified in the registry data
Starship Child Health, Te Toka Tumai, Auckland — Auckland, 1023, New Zealand — Site recruitment status not specified in the registry data

Study details

Start date: December 1, 2026
Primary completion date: December 1, 2034
Completion date: December 1, 2036
First posted: September 21, 2026
Collaborators: Berry Consultants, Menzies School of Health Research

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07830108
Registry last updated: October 7, 2026
QualifiedStudies registry data refreshed: October 12, 2026
QualifiedStudies record fetched: October 12, 2026

View NCT07830108 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Arthritis studies | Clinical trial FAQ