Transcranial Random Noise (tRNS) for BPSD in Alzheimer's Disease: A Double-blind Randomized Controlled Trial

NCT ID
NCT07827196
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Anhui Medical University
Conditions
Alzheimer Disease, BPSD (Behavioral and Psychological Symptoms of Dementia), Electroencephalography, Transcranial Random Noise Stimulation (tRNS)

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Transcranial Random Noise (tRNS) for Behavioral and Psychological Symptoms in Alzheimer's Disease (BPSD): A Randomized, Double-blind, Sham-Controlled Trial

Enrollment: 40 participants (Estimated).

What is being studied

  • Device: High frequency transcranial random noise
  • Device: Sham high frequency transcranial random noise

Who may be eligible

Ages
45 Years to 84 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Subject diagnosed with early Alzheimer's disease or related diseases according to NINCDS-ACDRADA criteria. * Subjects must have a MMSE score between 10 and 27,indicating mild cognitive impairment or dementia * CDR score ≤ 2 * Subject under treatment by IAChE for at least 3 months. * psychotropic treatments are tolerated if they were administered and unchanged for at least 3 months Exclusion Criteria: * NPI ≥ 4 * CDR \> 2 * Any history or clinical signs of other severe psychiatric illnesses (like major depression,psychosis or obsessive compulsive disorder). * History of head injury,stroke,or other neurologic disease. * Organic brain defects on T1 or T2 images. * History of seizures or unexplained loss of consciousness. * Implanted pacemaker,medication pump,vagal stimulator,deep brain stimulator. * Family history of medication refractory epilepsy. * History of substance abuse within the last 6 months.

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: China

  • Anhui, China: 1

Sample of listed locations

  • Anhui Medical University, Hefei, Anhui 230032 — Hefei, Anhui, 230032, China — Recruiting

Study details

Start date
September 1, 2026
Primary completion date
September 1, 2027
Completion date
September 1, 2027
First posted
September 18, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07827196
Registry last updated
September 18, 2026
QualifiedStudies registry data refreshed
September 28, 2026
QualifiedStudies record fetched
September 28, 2026

View NCT07827196 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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