Quad Shot Versus Split Course Radiotherapy in Incurable Head and Neck Cancer

Inclusion Criteria: * Adult patients (18 years and older) with a histopathological diagnosis of incurable squamous cell carcinoma of the head and neck, not candidates for curative-intent treatment. * Metastatic or locally advanced unresectable disease, in a strictly palliative setting. * Medical indication for palliative radiotherapy. * Performance status: Karnofsky 50 or higher or ECOG 3 or lower. * Clinical capacity to receive radiotherapy in an outpatient setting. * Estimated life expectancy greater than 3 months. * Presence of at least one measurable lesion according to RECIST 1.1 criteria. * Logistical capacity and willingness to adhere to follow-up clinical and radiological controls up to 6 months post-treatment. * Signed informed consent. Exclusion Criteria: * History of previous radiotherapy to the same anatomical region to be treated. * Diagnosis of a second active malignancy that could interfere with the evaluation of oncological outcomes. * Presence of clinical instability or severe comorbidities that contraindicate radiotherapy treatment. * Severe cognitive or psychiatric alterations that prevent the understanding of the nature of the study, signing the consent form, or adherence to the protocol. * Women who are pregnant or breastfeeding