Noninvasive Neuromodulation Of The Subjective Value Network In Chronic Pain

NCT ID
NCT07798908
Registry status
Not yet recruiting
Study type
Interventional
Phase
Phase 1
Sponsor
National Institute of Neurological Disorders and Stroke (NINDS)
Conditions
Chronic Neurogenic Pain

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Official title: Noninvasive Neuromodulation of the Subjective Value Network in Chronic Pain

Enrollment: 9 participants (Estimated).

What is being studied

  • Intervention: Magnetic Field Therapy
  • Intervention: salicylhydroxamic acid
  • Other: Sham
  • Intervention: Therapeutics
  • Device: Transcranial magnetic stimulation
  • Intervention: Transcranial Magnetic Stimulation

Who may be eligible

Ages
18 Years to 100 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

* INCLUSION CRITERIA: In order to be eligible to participate in this study, an individual must meet all of the following criteria: * Participant must be willing to comply with all study procedures and be available for the duration of the study. * Male and female patients of 18 years of age or older. * Diagnosed with peripheral or central neuropathic pain of at least three months duration and phenotyped by the PRC under protocol 16-AT-0077, and on a stable pain medication regimen * In stable health as determined by study personnel, and without acute medical or mental illness for the past six weeks EXCLUSION CRITERIA: An individual who meets any of the following criteria will be excluded from participation in this study: * Concurrent epilepsy or history of seizure in the last year * Inability to provide informed consent * Ferromagnetic metal in the cranial cavity or eye, implanted neural stimulator, cochlear implant, or ocular foreign body * Implanted electronics contraindicated for MRI or TMS, such as cardiac pacemaker or auto-defibrillator or pumps * Non-removable body piercings * Claustrophobia severe enough to preclude MRI * Inability to lie supine for 1 hour * Members of the NINDS BNU or NIHPRC * Individuals with elevated risk and potential contraindications to MRI, as defined by the NIH NMR center guidelines. * Known hearing loss, as assessed by asking the potential participant whether they have hearing loss * Have difficulties with communication that make subjective pain assessment impossible or unreliable * Have active medical or psychiatric health issues that create additional and substantial adverse risks related to study procedures * Pregnant participants or participants planning to become pregnant during the study. At enrollment/baseline, pregnancy status will be assessed by asking participants capable of becoming pregnant whether they are pregnant or planning to become pregnant during the study. Before each fMRI, participants capable of becoming pregnant must have a negative urine pregnancy test to continue with the fMRI.

Study locations

1 study location is listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: United States

  • Maryland, United States: 1

Sample of listed locations

  • National Institutes of Health Clinical Center — Bethesda, Maryland, 20892, United States — Site recruitment status not specified in the registry data

Study details

Start date
December 1, 2026
Primary completion date
December 1, 2030
Completion date
December 1, 2030
First posted
September 2, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07798908
Registry last updated
September 28, 2026
QualifiedStudies registry data refreshed
October 2, 2026
QualifiedStudies record fetched
October 2, 2026

View NCT07798908 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Chronic Pain studies | Clinical trial FAQ