High- vs Standard-Dose Intravenous Magnesium for Acute Headache

NCT ID
NCT07779486
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
University of Monastir
Conditions
Acute Headache, Cluster Headache, Migraine, Tension-type Headache

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Intravenous Magnesium Sulfate Versus Paracetamol for the Treatment of Acute Non-Traumatic Headache in the Emergency Department: A Randomized Double-Blind Controlled Trial

Enrollment: 300 participants (Estimated).

What is being studied

  • Intervention: Acetaminophen
  • Intervention: Acetanilides
  • Intervention: Amides
  • Intervention: Amines
  • Intervention: Anilides
  • Intervention: Aniline Compounds
  • Intervention: Inorganic Chemicals
  • Intervention: Magnesium Compounds
  • Intervention: Magnesium Sulfate
  • Drug: Magnesium Sulfate 2 grams
  • Drug: Magnesium Sulfate 4 G
  • Intervention: Organic Chemicals
  • Drug: Paracetamol 1 g
  • Intervention: Sulfates
  • Intervention: Sulfur Acids
  • Intervention: Sulfur Compounds
  • Intervention: Sulfuric Acids

Who may be eligible

Ages
18 Years to no maximum
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Age ≥18 years * Presentation to the emergency department with acute non-traumatic headache of less than 72 hours duration * Diagnosis consistent with a primary headache disorder, including: * Migraine * Tension-type headache * Cluster headache (according to ICHD-3 criteria) * Moderate to severe pain intensity (VAS ≥5/10) * Ability to understand the study procedures and provide informed consent Exclusion Criteria: * Suspected or confirmed secondary headache (e.g., intracranial hemorrhage, infection, mass lesion) * Recent head trauma * Known hypersensitivity or contraindication to magnesium sulfate or paracetamol * Use of analgesic medication within the previous 6 hours * Pregnancy or breastfeeding * Severe renal insufficiency or conditions contraindicating magnesium administration * Hemodynamic instability or clinically significant cardiac conduction disorders Prior participation in this study

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: Tunisia

Sample of listed locations

  • University Hospital Fattouma Bourguiba Monastir — Monastir, 5000, Tunisia — Recruiting

Study details

Start date
June 1, 2026
Primary completion date
December 31, 2029
Completion date
December 31, 2030
First posted
August 21, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07779486
Registry last updated
August 21, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT07779486 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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