The Effect of 5-hydroxytryptophan on ADHD Traits and Eye Movements

NCT ID
NCT07777328
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
University of Sheffield
Conditions
Attention Deficit and Hyperactivity Disorder (ADHD), Attention Deficit Hyperactivity Disorder in Adults, Attention Deficits

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: The Effect of 5-hydroxytryptophan on Microsaccades and Distractibility in Individual With High Levels of ADHD Traits: a Randomised, Double-blind Trial

Enrollment: 150 participants (Estimated).

What is being studied

  • Intervention: 5-Hydroxytryptophan
  • Dietary supplement: 5-hydroxytryptophan (food supplement) 200mg
  • Dietary supplement: 5-hydroxytryptophan (food supplement) 300mg
  • Intervention: Amino Acids
  • Intervention: Amino Acids, Aromatic
  • Intervention: Amino Acids, Cyclic
  • Intervention: Amino Acids, Peptides, and Proteins
  • Intervention: Diet, Food, and Nutrition
  • Intervention: Dietary Supplements
  • Intervention: Food
  • Intervention: Food and Beverages
  • Intervention: Physiological Phenomena
  • Other: Placebo
  • Intervention: Tryptophan

Who may be eligible

Ages
18 Years to 65 Years
Sex
All
Healthy volunteers accepted
Yes

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * 18-65 years of age * Normal or corrected to normal vision with contact lenses. * Score of \<9 or \>14 on the ASRS v5 (assessed in pre screen questionnaire) Exclusion Criteria: * Current use of psychostimulant medication or medication for the treatment of ADHD * Current use of medications known to impact the serotonergic system (e.g., SSRIs). * Smoking or vaping * Pregnancy * Breast feeding * Lactose intolerance * Veganism * Dyslexia

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United Kingdom

  • South Yorkshire, United Kingdom: 1

Sample of listed locations

  • University of Sheffield — Sheffield, South Yorkshire, S10 2TN, United Kingdom — Recruiting

Study details

Start date
November 25, 2025
Primary completion date
February 1, 2027
Completion date
June 1, 2027
First posted
August 20, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07777328
Registry last updated
August 20, 2026
QualifiedStudies registry data refreshed
September 28, 2026
QualifiedStudies record fetched
September 28, 2026

View NCT07777328 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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