Aging and Exercise Impacts on Glymphatic Function
- NCT ID
- NCT07775196
- Registry status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Sponsor
- University of Texas Southwestern Medical Center
- Conditions
- Aging and Exercise Impacts on Glymphatic Function
Overview
ClinicalTrials.gov lists this study as Not yet recruiting.
Official title: Impact of Aging and Exercise on Glymphatic Function Using Multi-modal MRI
Enrollment: 240 participants (Estimated).
What is being studied
- Procedure: Acute Aerobic exercise
Who may be eligible
- Ages
- 25 Years to 75 Years
- Sex
- All
- Healthy volunteers accepted
- Yes
ClinicalTrials.gov lists the following eligibility criteria.
Inclusion Criteria:
* age 25-75 years old
* cognitively unimpaired (CU)
* Mini-Mental State Examination (MMSE) score ≥27 at enrollment screening
* matched gender
* all racial/ethnic groups
Exclusion Criteria:
* pregnant women
* history of stroke or other major cerebrovascular disease;
* diagnosis of Alzheimer's disease (AD) or other types of dementia;
* diagnosis of major neurologic and psychiatric disorders (e.g., Parkingson's disease, major depression);
* history of prior head trauma, significant autoimmune disorders,
* sleep apnea;
* major systemic illness likely to affect the central nervous system, e.g., uncontrolled diabetes, severe cardiovascular disease, cancer, etc.;
* prior or current alcoholism or drug abuse;
* resistant hypertension (SBP ≥140 or DBP ≥ 90 mmHg despite 3 antihypertensive drugs at maximal doses);
* orthostatic hypotension defined as the third standing systolic blood pressure (SBP) \< 100mmHg; any contraindications to having a MRI, e.g., claustrophobia, pacemaker or other medical device of metal;
* any conditions judged by the investigators to be medically inappropriate, risky or likely to cause poor study compliance.
Study locations
No study locations are listed in the registry data.
Study details
- Start date
- December 1, 2026
- Primary completion date
- December 1, 2029
- Completion date
- December 1, 2029
- First posted
- August 20, 2026
- Collaborators
- National Institute on Aging (NIA)
Source and update information
- Source
- ClinicalTrials.gov
- NCT ID
- NCT07775196
- Registry last updated
- October 5, 2026
- QualifiedStudies registry data refreshed
- October 12, 2026
- QualifiedStudies record fetched
- October 12, 2026
View NCT07775196 on ClinicalTrials.gov
Trial information can change. Confirm current study details with the study team or the registry.
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