Treatment Resistance in Psychiatric Disorders: the Search for Biological Markers Predictive of Response to Treatment

NCT ID
NCT07741981
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Centre Hospitalier St Anne
Conditions
Bipolar Disorder (BD), Catatonia, Obsessive Compulsive Disorder (OCD), Schizophrenia, Treatment Resistant Depression (TRD)

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 700 participants (Estimated).

What is being studied

  • Intervention: Biopsy
  • Biological: Blood sampling, lumbar puncture, stool sampling, skin microbiopsy and psychometrics scales
  • Intervention: Blood Specimen Collection
  • Intervention: Clinical Laboratory Techniques
  • Intervention: Diagnosis
  • Intervention: Diagnostic Techniques and Procedures
  • Intervention: Diagnostic Techniques, Neurological
  • Intervention: Investigative Techniques
  • Intervention: Punctures
  • Intervention: Specimen Handling
  • Intervention: Spinal Puncture
  • Intervention: Surgical Procedures, Operative
  • Intervention: Therapeutics

Who may be eligible

Ages
18 Years to no maximum
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Patient aged ≥ 18 years old; * Patient suffering from a psychiatric disorder according to DSM-5 criteria; * Patient with drug-resistant disease according to the definition of the protocol * Patient starting a new treatment for his pathology; * Patient informed and having signed an informed consent; * Patient covered by the social security system. Exclusion Criteria: * Patient with major neurocognitive disorder diagnosed (dementia syndrome) * Pregnant, laboring, or breastfeeding female patients * Patient deprived of liberty by judicial or administrative decision. Patient in psychiatric care under constraints may be included. * For patients accepting the lumbar punction: patients who are unable to control themselves and are likely to engage in physical or violent behavior.

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: France

Sample of listed locations

  • GHU Paris - Psychiatrie et Neurosciences — Paris, 75014, France — Recruiting

Study details

Start date
August 20, 2026
Primary completion date
November 1, 2036
Completion date
September 1, 2038
First posted
August 3, 2026
Collaborators
GHU Paris Psychiatry & Neurosciences

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07741981
Registry last updated
September 21, 2026
QualifiedStudies registry data refreshed
September 28, 2026
QualifiedStudies record fetched
September 28, 2026

View NCT07741981 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Clinical trial FAQ