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A Study to Evaluate the Effects of Enicepatide in Participants With Obesity or Overweight, With or Without Type 2 Diabetes

NCT ID: NCT07670416
Registry status: Recruiting
Study type: Not specified in the registry data
Phase: Phase 3
Sponsor: Hoffmann-La Roche

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 300 participants (Estimated).

What is being studied

No interventions are listed in the registry data.

Who may be eligible

Ages: Not specified in the registry data
Sex: Not specified in the registry data
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Body mass index (BMI) ≥24.0 kilograms per meter squared (kg/m\^2) for participants with type 2 diabetes mellitus (T2DM) * BMI ≥28.0 kg/m\^2 or BMI ≥24.0 and \<28.0 kg/m\^2 and diagnosed with at least one weight-related comorbidity (prediabetes, hypertension, dyslipidemia, fatty liver, obstructive sleep apnea, or weight-related cardiovascular disease) for participants without T2DM * Agreement to adhere to the contraception requirements Exclusion Criteria: * History of Type 1 diabetes mellitus (T1DM) * Obesity induced by other endocrinologic disorders * Any planned major medical procedure or surgery during the study * History of significant active or unstable major depressive disorder (MDD) or other severe psychiatric disorder * Any lifetime history of suicide attempt * History of any hematologic conditions that may interfere with HbA1c measurement * History of acute or chronic pancreatitis or clinically signiﬁcant gallbladder disease * Treatment with any approved or investigational GLP-1-RA-based therapy within 6 months prior to randomization * Treatment with other investigational therapy within 3 months prior to randomization or less than 5 elimination half-lives prior to randomization, whichever is longer * Known allergy to any component of the study drug formulation or any other condition that is a contraindication to GLP-1 RAs or GLP-1/GIP RAs

Study locations

21 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: China

Henan, China: 1
Shaanxi, China: 1
Zhejiang, China: 1

Sample of listed locations

The Second Affiliated Hospital of Zhengzhou University — Zhengzhou, Henan, 450014, China — Site recruitment status not specified in the registry data
Yan'an University Xianyang Hospital — Xianyang, Shaanxi, 712000, China — Site recruitment status not specified in the registry data
The First Affiliated Hospital of Ningbo University(Ningbo First Hospital) — Ningbo, Zhejiang, 315010, China — Site recruitment status not specified in the registry data
Peking University People's Hospital — Beijing, 100044, China — Site recruitment status not specified in the registry data
The Second Hospital of Jilin University — Changchun, 130041, China — Site recruitment status not specified in the registry data
The Second Affiliated Hospital of Anhui Medical University — Hefei, 230601, China — Site recruitment status not specified in the registry data
The Fourth Affiliated Hospital of Harbin Medical University — Herbin, 150001, China — Site recruitment status not specified in the registry data
Huai'an First People's Hospital — Huai'an, China — Site recruitment status not specified in the registry data
Huzhou Central Hospital — Huzhou, 313000, China — Site recruitment status not specified in the registry data
Jinan Central Hospital — Jinan, 250013, China — Site recruitment status not specified in the registry data
Hebei Petro China Central Hospital — Langfang, 065000, China — Site recruitment status not specified in the registry data
Luoyang Third People's Hospital — Luoyang, 471000, China — Site recruitment status not specified in the registry data
The Affiliated Jiangning Hospital of Nanjing Medical University — Nanjing, 211100, China — Site recruitment status not specified in the registry data
Shanghai East Hospital — Shanghai, 200120, China — Site recruitment status not specified in the registry data
Shanghai Fifth People's Hospital Affiliated to Fudan University — Shanghai, 201304, China — Site recruitment status not specified in the registry data
Shanghai Tenth People's Hospital — Shanghai, 200072, China — Site recruitment status not specified in the registry data
Tongren Hospital, Affiliated to Shanghai Jiao Tong University School of Medicine — Shanghai, 200336, China — Site recruitment status not specified in the registry data
Shenyang Fifth People Hospital — Shenyang, 110074, China — Site recruitment status not specified in the registry data
The People's Hospital of Liaoning Province — Shenyang, 110016, China — Site recruitment status not specified in the registry data
Hebei Medical University - The Second Hospital — Shijiazhuang, 050004, China — Site recruitment status not specified in the registry data
Zibo Municipal Hospital. — Zibo, 255400, China — Site recruitment status not specified in the registry data

Study details

Start date: July 3, 2026
Primary completion date: February 24, 2028
First posted: June 26, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07670416
Registry last updated: September 10, 2026
QualifiedStudies registry data refreshed: September 21, 2026

View NCT07670416 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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