NON-INVASIVE BRAIN STIMULATION FOR MEMORY LOSS IN EARLY ALZHEIMER'S DISEASE

NCT ID
NCT07667478
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Chi-Ying (Roy) Lin
Conditions
Alzheimer s Disease, Mild Cognitive Impairment (MCI) Due to Alzheimer's Disease, Mild Dementia

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 40 participants (Estimated).

What is being studied

  • Intervention: Magnetic Field Therapy
  • Device: repetitive transcranial magnetic stimulation (rTMS)
  • Other: sham repetitive transcranial magnetic stimulation rTMS
  • Intervention: Therapeutics
  • Intervention: Transcranial Magnetic Stimulation

Who may be eligible

Ages
55 Years to 90 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: Participants must meet all of the following inclusion criteria to be eligible for enrollment: * A clinical diagnosis of early AD, defined as either mild cognitive impairment (MCI) due to AD or mild dementia due to AD; * Evidence of cognitive impairment, characterized by a MMSE score between 20 and 28 and/or a CDR-Sum of Boxes score between 0.5 and 8, consistent with the contemporary definitions used in early AD in clinical trials; and * Biomarker confirmation of AD pathology, demonstrated by a positive plasma phosphorylated tau-217 (p-tau217) result according to the 2024 National Institute on Aging-Alzheimer's Association (NIA-AA) diagnostic guidelines. Exclusion Criteria: * Exclusion criteria include evidence of other neurological, psychiatric, or systemic conditions that could cause cognitive and functional impairments (e.g., substantial concomitant cerebrovascular disease, alcoholism, certain medications that could have a substantial effect on cognition, untreated major depressive disorder, and heart, renal or hepatic failure). * Individuals who have contraindications to receiving rTMS, including a history of seizures or any non-removable metal in their heads or within 12 inches of the TMS coil will be excluded.

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • Texas, United States: 1

Sample of listed locations

  • Baylor College of Medicine — Houston, Texas, 77030, United States — Recruiting

Study details

Start date
April 15, 2026
Primary completion date
April 14, 2031
Completion date
April 14, 2031
First posted
June 25, 2026
Collaborators
Texas Alzheimer's Research and Care Consortium

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07667478
Registry last updated
October 1, 2026
QualifiedStudies registry data refreshed
October 12, 2026
QualifiedStudies record fetched
October 12, 2026

View NCT07667478 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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