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A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)

NCT ID: NCT07654374
Registry status: Recruiting
Study type: Not specified in the registry data
Phase: Phase 3
Sponsor: Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 1100 participants (Estimated).

What is being studied

No interventions are listed in the registry data.

Who may be eligible

Ages: Not specified in the registry data
Sex: Not specified in the registry data
Healthy volunteers accepted: Yes

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Signed Informed Consent * Have a BMI ≥27.0 kg/m2 at Screening * Have a diagnosis of T2DM according to the WHO classification or other locally applicable standards, with HbA1c ≥6.5% (≥53 mmol/mol) to ≤10% (86 mmol/mol) at Screening Exclusion Criteria: * Have type 1 diabetes, history of ketoacidosis or hyperosmolar state/coma, or any other types of diabetes except T2DM. * Have had 1 or more episode of severe hypoglycemia and/or 1 or more episode of hypoglycemia unawareness within 180 days prior to Screening. * Are currently receiving or planning to receive treatment for diabetic retinopathy and/or macular edema * Self-reported change in body weight \>5 kg (11 pounds) within 3 months before Screening. * Have prior or planned surgical or non-surgical treatment for obesity.

Study locations

71 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: United States

Alabama, United States: 1
Arizona, United States: 4
Arkansas, United States: 1
California, United States: 7
Connecticut, United States: 1
Florida, United States: 8
Georgia, United States: 5
Idaho, United States: 1
Iowa, United States: 2
Kansas, United States: 1
Maryland, United States: 1
Massachusetts, United States: 1
Minnesota, United States: 2
Mississippi, United States: 2
Missouri, United States: 5
Montana, United States: 1
Nebraska, United States: 1
Nevada, United States: 1
New York, United States: 3
North Carolina, United States: 5
Ohio, United States: 1
Oklahoma, United States: 3
Oregon, United States: 1
Pennsylvania, United States: 1
South Carolina, United States: 1
Tennessee, United States: 1
Texas, United States: 5
Utah, United States: 1
Virginia, United States: 3
Washington, United States: 1

Sample of listed locations

ACCOMPLISH-2 Research Site — Birmingham, Alabama, 35242, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Chandler, Arizona, 85225, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Phoenix, Arizona, 85028, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Sun City West, Arizona, 85375, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Tucson, Arizona, 85741, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Little Rock, Arkansas, 72211, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Escondido, California, 92025, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Fountain Valley, California, 92708, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — La Jolla, California, 92123, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Lake Forest, California, 92630, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Rolling Hills Estates, California, 90274, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — San Diego, California, 92108, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Tustin, California, 92780, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Waterbury, Connecticut, 06708, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Clearwater, Florida, 33756, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Fort Myers, Florida, 33912, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Jacksonville, Florida, 32216, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Leesburg, Florida, 34748, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Miami, Florida, 33136, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Ocala, Florida, 34470, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Ocoee, Florida, 34761, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Pembroke Pines, Florida, 33027, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Atlanta, Georgia, 30329, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Columbus, Georgia, 31904, United States — Site recruitment status not specified in the registry data
ACCOMPLISH-2 Research Site — Lawrenceville, Georgia, 30046, United States — Site recruitment status not specified in the registry data

Study details

Start date: July 17, 2026
Primary completion date: September 1, 2028
First posted: June 17, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07654374
Registry last updated: September 11, 2026
QualifiedStudies registry data refreshed: September 21, 2026

View NCT07654374 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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