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A Chronic Pain Master Protocol (CPMP): A Study of LY4065967 in Participants With Osteoarthritis Pain

NCT ID: NCT07641517
Registry status: Recruiting
Study type: Interventional
Phase: Phase 2
Sponsor: Eli Lilly and Company
Conditions: Chronic Pain, Osteoarthritis, Knee

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Randomized, Placebo-Controlled, Phase 2 Clinical Trial to Evaluate LY4065967 for the Treatment of Osteoarthritis

Enrollment: 150 participants (Estimated).

What is being studied

Drug: LY4065967
Drug: Placebo

Who may be eligible

Ages: 40 Years to no maximum
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Have presence of index knee pain for more than 12 weeks at screening * Have an x-ray supporting diagnosis of osteoarthritis according to the American College of Rheumatology with a Kellgren-Lawrence grade 2 to 4 radiographic classification of index knee * Have a body mass index ≤40 kilograms per meter squared (kg/m²) (inclusive) * Have stable glycemic control as indicated by a glycated hemoglobin (HbA1c) less than or equal to 10 at time of screening Exclusion Criteria: * Are pregnant or breastfeeding * Have had a surgical procedure or therapeutic injection in the affected knee within 3 months prior to screening * Have presence of surgical hardware or other foreign body in the index knee * Have ongoing complex regional pain syndrome or other concurrent medical condition that could interfere with the evaluation of pain in the index knee. * Have had any joint replacement of the lower extremity, such as hip, knee or ankle, in the 6 months prior to screening * Have an abnormal blood pressure (BP) (systolic BP greater than 140 millimeters mercury (\>140 mm Hg) and diastolic BP\>90 mm Hg) at screening * Have history or current clinically significant cardiac disease, including arrhythmia, aortic aneurysm, heart failure, current electrolyte abnormalities, or any other conditions that could predispose to arrhythmia in the judgement of the investigator

Study locations

37 study locations are listed.

Recruiting site status is explicitly provided for 37 locations; 37 are listed as Recruiting.

Countries: Puerto Rico, United States

Alabama, United States: 1
Arizona, United States: 2
California, United States: 3
Connecticut, United States: 1
Florida, United States: 12
Georgia, United States: 1
Illinois, United States: 1
Louisiana, United States: 1
Massachusetts, United States: 2
Michigan, United States: 1
Missouri, United States: 2
New York, United States: 1
North Dakota, United States: 1
Ohio, United States: 1
Oklahoma, United States: 1
Pennsylvania, United States: 1
Texas, United States: 2
Washington, United States: 2

Sample of listed locations

Ponce Medical School Foundation Inc. — Ponce, 00716, Puerto Rico — Recruiting
Central Research Associates — Birmingham, Alabama, 35205, United States — Recruiting
Arizona Research Center — Phoenix, Arizona, 85053, United States — Recruiting
Synexus Clinical Research US, Inc. — Phoenix, Arizona, 85020, United States — Recruiting
Desert Oasis Healthcare Medical Group — Palm Springs, California, 92262, United States — Recruiting
Artemis Institute for Clinical Research — Riverside, California, 92503, United States — Recruiting
Artemis Institute for Clinical Research — San Diego, California, 92123, United States — Recruiting
CMR of Greater New Haven — Hamden, Connecticut, 06517, United States — Recruiting
Bradenton Research Center, Inc. — Bradenton, Florida, 34205, United States — Recruiting
Accel Research Sites - DeLand Clinical Research Unit — DeLand, Florida, 32720, United States — Recruiting
K2 MEDICAL Research THE VILLAGES — Lady Lake, Florida, 32159, United States — Recruiting
K2 Medical Research ORLANDO — Maitland, Florida, 32751, United States — Recruiting
Merritt Island Medical Research, LLC — Merritt Island, Florida, 32952, United States — Recruiting
New Horizon Research Center — Miami, Florida, 33165, United States — Recruiting
Suncoast Research Group — Miami, Florida, 33135, United States — Recruiting
Suncoast Clinical Research, Inc. — New Port Richey, Florida, 34652, United States — Recruiting
Renstar Medical Research — Ocala, Florida, 34470, United States — Recruiting
Precision Clinical Research — Sunrise, Florida, 33351, United States — Recruiting
Charter Research - Lady Lake — The Villages, Florida, 32162, United States — Recruiting
Conquest Research — Winter Park, Florida, 32789, United States — Recruiting
North Georgia Clinical Research — Woodstock, Georgia, 30189, United States — Recruiting
Northwestern University — Chicago, Illinois, 60611, United States — Recruiting
DelRicht Research — New Orleans, Louisiana, 70115, United States — Recruiting
Lucida Clinical Trials — New Bedford, Massachusetts, 02740, United States — Recruiting
MedVadis Research Corporation — Waltham, Massachusetts, 02451, United States — Recruiting

Study details

Start date: June 25, 2026
Primary completion date: April 1, 2027
Completion date: April 1, 2027
First posted: June 11, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07641517
Registry last updated: September 4, 2026
QualifiedStudies registry data refreshed: October 5, 2026
QualifiedStudies record fetched: October 5, 2026

View NCT07641517 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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