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Study of EVO756 in Adults With Migraine

NCT ID: NCT07616128
Registry status: Recruiting
Study type: Interventional
Phase: Phase 2
Sponsor: Evommune, Inc.
Conditions: Migraine

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Randomized, Double-Blind, Placebo Controlled Study Evaluating the Efficacy and Safety of EVO756 for the Prevention of Migraine in Adults

Enrollment: 330 participants (Estimated).

What is being studied

Drug: EVO756, Dose 1
Drug: EVO756, Dose 2
Drug: Placebo

Who may be eligible

Ages: 18 Years to 64 Years
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Key Inclusion Criteria: * Adults aged 18 to \<65 years * Migraine with or without aura, per ICHD-3 criteria * History of failure with prior preventive migraine treatments * Not currently using migraine preventive therapy Key Exclusion Criteria: * Difficulty distinguishing migraine from other headache types or presence of other primary headache disorders * Use of certain medications * Any clinically significant medical, psychiatric, neurological, cardiovascular, or laboratory abnormalities

Study locations

35 study locations are listed.

Recruiting site status is explicitly provided for 35 locations; 35 are listed as Recruiting.

Countries: Canada, New Zealand, United States

Quebec, Canada: 1
Arizona, United States: 1
California, United States: 4
Connecticut, United States: 2
Florida, United States: 7
Georgia, United States: 2
Massachusetts, United States: 2
Michigan, United States: 2
New Jersey, United States: 1
New York, United States: 1
North Carolina, United States: 2
Ohio, United States: 1
South Carolina, United States: 1
Tennessee, United States: 1
Texas, United States: 4
Virginia, United States: 1
West Virginia, United States: 1

Sample of listed locations

Centre de Recherche St-Louis — Québec, Quebec, G1W 4R4, Canada — Recruiting
Momentum Clinical Research - Wellington — Wellington, 6021, New Zealand — Recruiting
Trialsphere Corp — Chandler, Arizona, 85286, United States — Recruiting
Buena Park Research Center — Buena Park, California, 90620, United States — Recruiting
Neuro Pain Research Center — Fresno, California, 93710, United States — Recruiting
CA Medical Clinic for Headache — Los Angeles, California, 90067, United States — Recruiting
Diablo Clinical Research dba Flourish Research — Walnut Creek, California, 94598, United States — Recruiting
Hasbani Neurology — New Haven, Connecticut, 06511, United States — Recruiting
New England Institute for Neurology and Headache — Stamford, Connecticut, 06905, United States — Recruiting
Clinical Neuroscience Solutions, Inc. — Jacksonville, Florida, 32256, United States — Recruiting
Apple Medical Research Group, Inc — Miami, Florida, 331216, United States — Recruiting
Blessed Healthcase & Research — Miami, Florida, 33173, United States — Recruiting
Florida Research Center, Inc. — Miami, Florida, 33174, United States — Recruiting
Clinical Neuroscience Solutions, Inc. — Orlando, Florida, 32819, United States — Recruiting
Vantage Clinical Trials — Tampa, Florida, 33614, United States — Recruiting
Premiere Research Institute at Palm Beach Neurology — West Palm Beach, Florida, 33407, United States — Recruiting
Clinical Integrative Research Center of Atlanta — Atlanta, Georgia, 30328, United States — Recruiting
Accel Research Site-Decatur-Alcanza — Decatur, Georgia, 30030, United States — Recruiting
Neurology Center of New England P.C. — Foxborough, Massachusetts, 02035, United States — Recruiting
Mass Institute of Clinical Research — Westborough, Massachusetts, 01581, United States — Recruiting
Michigan Headache and Neurological Institute — Ann Arbor, Michigan, 48104, United States — Recruiting
Quest Research Institute-Alcanza — Farmington Hills, Michigan, 48334, United States — Recruiting
Bio Behavoural health — Toms River, New Jersey, 08755, United States — Recruiting
Clinosis - Dent Neurologic Instite — Amherst, New York, 14226, United States — Recruiting
Asheville Neurology Specialists, Pa — Asheville, North Carolina, 28806, United States — Recruiting

Study details

Start date: July 29, 2026
Primary completion date: October 1, 2027
Completion date: November 1, 2027
First posted: June 1, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07616128
Registry last updated: October 2, 2026
QualifiedStudies registry data refreshed: October 5, 2026
QualifiedStudies record fetched: October 5, 2026

View NCT07616128 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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