Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery

NCT ID
NCT07434427
Registry status
Recruiting
Study type
Interventional
Phase
Phase 4
Sponsor
Medical University of Silesia
Conditions
Acute Postoperative Pain, Chronic Postoperative Pain, Toracosurgery, Video-assisted Thoracis Surgery (VATS)

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Comparison of the Efficacy and Safety of Intravenous Buprenorphine Administered Via PCA System Versus Oxycodone in the Management of Postoperative Pain After Video-Assisted Thoracoscopic Surgery - A Prospective, Randomized Clinical Trial

Enrollment: 200 participants (Estimated).

What is being studied

  • Intervention: Alkaloids
  • Intervention: Buprenorphine
  • Intervention: Codeine
  • Drug: Group B (Buprenorphine)
  • Drug: Group O (Oxycodone)
  • Intervention: Heterocyclic Compounds
  • Intervention: Heterocyclic Compounds, 4 or More Rings
  • Intervention: Heterocyclic Compounds, Bridged-Ring
  • Intervention: Heterocyclic Compounds, Fused-Ring
  • Intervention: Morphinans
  • Intervention: Morphine Derivatives
  • Intervention: Opiate Alkaloids
  • Intervention: Oxycodone
  • Intervention: Phenanthrenes
  • Intervention: Polycyclic Aromatic Hydrocarbons
  • Intervention: Polycyclic Compounds

Who may be eligible

Ages
18 Years to 75 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * qualification for elective thoracic surgery performed using the VATS technique, physical status ASA I-III, anticipated use of PCA in the postoperative period, patient's consent to participate in the study. Exclusion Criteria: * inability to provide informed consent, * hypersensitivity to opioids or study medications, * chronic opioid therapy, * previously diagnosed chronic pain, * chronic use of analgesic medications, * disorders of consciousness preventing appropriate use of the PCA pump, * severe renal or hepatic insufficiency, * pregnancy or breastfeeding, * clinically relevant drug interactions (rifampicin, carbamazepine, CYP3A4 inhibitors).

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: Poland

  • Silesian Voivodeship, Poland: 1

Sample of listed locations

  • Clinical Hospital No 1 — Zabrze, Silesian Voivodeship, 41-800, Poland — Recruiting

Study details

Start date
March 18, 2026
Primary completion date
May 1, 2027
Completion date
November 1, 2027
First posted
February 25, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07434427
Registry last updated
September 25, 2026
QualifiedStudies registry data refreshed
September 28, 2026
QualifiedStudies record fetched
September 28, 2026

View NCT07434427 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Chronic Pain studies | Clinical trial FAQ