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Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

NCT ID: NCT07353931
Registry status: Recruiting
Study type: Interventional
Phase: Phase 3
Sponsor: Eli Lilly and Company
Conditions: Osteoarthritis, Overweight or Obesity

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

Enrollment: 900 participants (Estimated).

What is being studied

Drug: Eloralintide
Drug: Placebo

Who may be eligible

Ages: 18 Years to no maximum
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening * Have a stable body weight (less than 5% body weight change) for 90 days prior to screening * Have tried at least once to lose weight through diet but were unsuccessful * Have osteoarthritis of the knee and at least one of the following conditions: * Be over 50 years old * Have morning knee stiffness that lasts about 30 minutes * Have a crackling or grinding sound or feeling in the knee Exclusion Criteria: * Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening) * Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening) * Have type 1 diabetes, type 2 diabetes, or any other type of diabetes * Have an active knee infection * Have had within 90 days prior to screening: * heart attack * stroke * coronary artery revascularization * unstable angina, or * hospitalization due to congestive heart failure * Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure * Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study locations

152 study locations are listed.

Recruiting site status is explicitly provided for 152 locations; 128 are listed as Recruiting.

Countries: Argentina, Belgium, Brazil, Canada, China, Czechia, Denmark, Germany, Japan, Puerto Rico, South Korea, Taiwan, United Kingdom, United States

Alabama, United States: 1
Arizona, United States: 4
California, United States: 4
Colorado, United States: 1
Florida, United States: 3
Georgia, United States: 1
Idaho, United States: 1
Illinois, United States: 1
Indiana, United States: 1
Kansas, United States: 1
Kentucky, United States: 1
Massachusetts, United States: 2
New York, United States: 4
Oklahoma, United States: 1
Pennsylvania, United States: 1
Texas, United States: 8
Utah, United States: 1
Virginia, United States: 1
Washington, United States: 1

Sample of listed locations

Antwerp University Hospital — Edegem, 2650, Belgium — Recruiting
Reuma Clinic, Locatie Jaarbeurslaan — Genk, 3600, Belgium — Recruiting
UZ Gent — Ghent, 9000, Belgium — Recruiting
Kormont — Kluisbergen, 9690, Belgium — Recruiting
UZ Leuven — Leuven, 3000, Belgium — Recruiting
Meclinas — Mechelen, 2800, Belgium — Recruiting
Apex Trials — Guelph, N1G 0B4, Canada — Recruiting
Diex Recherche Inc. Division Quebec — Québec, G1V 4T3, Canada — Recruiting
Stouffville Medical Research Institute Inc. — Stouffville, L4A 1H2, Canada — Recruiting
Dr. Anil K. Gupta Medicine Professional Corporation — Toronto, M9V 4B4, Canada — Recruiting
Maple Leaf Research — Toronto, M5G 1K2, Canada — Recruiting
Diex Recherche Inc. Division Victoriaville — Victoriaville, G6P 3Z8, Canada — Recruiting
Beijing Ji Shui Tan Hospital — Beijing, 100035, China — Recruiting
The First Afflilated Hospital of Bengbu Medical College — Bengbu, 233004, China — Recruiting
Jilin Province People's Hospital — Changchun, 130021, China — Recruiting
Xiangya Hospital Central South University — Changsha, 410008, China — Recruiting
2nd Affiliated Hospital Chongqing Medical Universi — Chongqing, 400000, China — Recruiting
The Second Affiliated hospital of Zhejiang University school of medicine — Hangzhou, 310052, China — Recruiting
The Second People's Hospital of Hefei — Hefei, 230011, China — Recruiting
Jinan Central Hospital — Jinan, 250013, China — Recruiting
The First Affiliated Hospital of Henan University of Science &Technology — Luoyang, 471003, China — Recruiting
Jiangsu Province Hospital — Nanjing, 210029, China — Recruiting
Nanjing First Hospital — Nanjing, 210006, China — Recruiting
The Second Affiliated Hospital of Nanjing Medical University — Nanjing, 210011, China — Recruiting
Zhongda Hospital Southeast University — Nanjing, 210009, China — Recruiting

Study details

Start date: February 9, 2026
Primary completion date: March 1, 2028
Completion date: May 1, 2028
First posted: January 21, 2026

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07353931
Registry last updated: September 22, 2026
QualifiedStudies registry data refreshed: October 5, 2026
QualifiedStudies record fetched: October 5, 2026

View NCT07353931 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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