Effectiveness and Safety of Intra-Articular Hyaluronic Acid Conjugated With Fibrinogen in Knee Osteoarthritis

NCT ID
NCT07323342
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Cao Kim Xoa
Conditions
Knee Osteoarthritis

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Evaluation of the Efficacy and Safety of Intra-Articular Hyaluronic Acid Conjugated With Fibrinogen in Patients With Knee Osteoarthritis

Enrollment: 31 participants (Estimated).

What is being studied

  • Device: Intra-articular hyaluronic acid conjugated with fibrinogen

Who may be eligible

Ages
45 Years to 75 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Male or female patients aged 45 to 75 years. * Diagnosed with primary knee osteoarthritis according to the American College of Rheumatology (ACR) 1991 criteria. * Vietnamese patients. * Patients who have provided written informed consent to participate in the study. * Patients with full-length standing lower limb radiographs showing a mechanical axis deviation of less than 10 degrees. * Body mass index (BMI) between 18.5 and 35 kg/m². Exclusion Criteria: * Active joint infection or systemic infection. * Presence of other joint diseases such as rheumatoid arthritis, gout, malignancy-related joint disease, or significant knee trauma. * Acute concomitant medical conditions such as high fever, acute myocardial infarction, or pneumonia. * Use of non-steroidal anti-inflammatory drugs (NSAIDs) within 10 days prior to enrollment or intra-articular corticosteroid injection within 3 months before enrollment. * Presence of knee joint effusion at the time of screening. * History of hypersensitivity or allergy to hyaluronic acid.

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: Vietnam

Sample of listed locations

  • Xuong Khop Viet clinic — Ho Chi Minh City, 700000, Vietnam — Recruiting

Study details

Start date
May 5, 2025
Primary completion date
October 1, 2026
Completion date
October 1, 2026
First posted
January 7, 2026

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT07323342
Registry last updated
September 3, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT07323342 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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