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Study to Assess the Effects of ALN-ANG3 in Adult Participants With Diabetic Kidney Disease

NCT ID: NCT07271186
Registry status: Recruiting
Study type: Not specified in the registry data
Phase: Phase 2
Sponsor: Regeneron Pharmaceuticals

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 195 participants (Estimated).

What is being studied

No interventions are listed in the registry data.

Who may be eligible

Ages: Not specified in the registry data
Sex: Not specified in the registry data
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Key Inclusion Criteria: 1. Medical history of type 2 diabetes and receiving medical therapy or lifestyle interventions for glucose management 2. Hemoglobin A1C (HbA1c) of 6.5 to 10% at screening 3. eGFR 30 to 90 mL/min/1.73 m\^2 using 2021 Chronic Kidney Disease-Epidemiology Collaboration-Estimated Glomerular Filtration Rate using Creatinine and Cystatin C (CKD-EPI eGFRcr-cys) equation at screening 4. Albuminuria: Urine Albumin to Creatinine Ratio (UACR) of 500 to 5000 mg/g at screening Key Exclusion Criteria: 1. Known medical history or clinical evidence indicative of non-diabetic renal disease 2. Renal disease that required treatment with systemic immunosuppressive therapy (prior or current), or a history of end-stage kidney disease requiring treatment with chronic dialysis or kidney transplantation 3. Medically unstable as assessed by the investigator or hospitalization (ie, \>24 hours) within 30 days of the screening visit NOTE: Other Protocol-Defined Inclusion/Exclusion Criteria Apply

Study locations

58 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: United States

Alabama, United States: 1
Arkansas, United States: 1
California, United States: 9
Connecticut, United States: 1
Florida, United States: 16
Georgia, United States: 1
Illinois, United States: 1
Louisiana, United States: 1
Michigan, United States: 2
Missouri, United States: 2
Nebraska, United States: 1
Nevada, United States: 1
New York, United States: 2
North Carolina, United States: 3
Pennsylvania, United States: 2
Tennessee, United States: 1
Texas, United States: 13

Sample of listed locations

Apogee Clinical Research, LLC — Huntsville, Alabama, 35801, United States — Site recruitment status not specified in the registry data
Applied Research Center of Arkansas — Little Rock, Arkansas, 72205, United States — Site recruitment status not specified in the registry data
AME Clinical Research — Huntington Beach, California, 92647, United States — Site recruitment status not specified in the registry data
Amicis Research Center — Northridge, California, 91325, United States — Site recruitment status not specified in the registry data
FOMAT - Vista del Mar Medical Group — Oxnard, California, 93036, United States — Site recruitment status not specified in the registry data
Central Coast Nephrology — Salinas, California, 93901, United States — Site recruitment status not specified in the registry data
North America Research Institute — San Dimas, California, 91773, United States — Site recruitment status not specified in the registry data
Amicis Research Center — Santa Clarita, California, 91355, United States — Site recruitment status not specified in the registry data
Valiance Clinical Research — Tarzana, California, 91356, United States — Site recruitment status not specified in the registry data
Amicis Research Center — Valencia, California, 91355, United States — Site recruitment status not specified in the registry data
National Institute of Clinical Research, Inc. — Victorville, California, 92392, United States — Site recruitment status not specified in the registry data
Yale University — New Haven, Connecticut, 06510, United States — Site recruitment status not specified in the registry data
D&H Doral Research Center — Doral, Florida, 33122, United States — Site recruitment status not specified in the registry data
AGA Clinical Trials — Hialeah, Florida, 33012, United States — Site recruitment status not specified in the registry data
Convenient Medical Center — Hialeah, Florida, 33013, United States — Site recruitment status not specified in the registry data
Elixia Hollywood — Hollywood, Florida, 33024, United States — Site recruitment status not specified in the registry data
D&H Pompano Research Center — Margate, Florida, 33063, United States — Site recruitment status not specified in the registry data
D&H National Research Centers, Inc — Miami, Florida, 33155, United States — Site recruitment status not specified in the registry data
LCC Medical Research Institute — Miami, Florida, 33126, United States — Site recruitment status not specified in the registry data
Regenerate Primary Medical Research, LLC — Miami, Florida, 33155, United States — Site recruitment status not specified in the registry data
Ocean Blue Medical Research Center - Internal Medicine — Miami Springs, Florida, 33166, United States — Site recruitment status not specified in the registry data
Innovia Research Center — Miramar, Florida, 33027, United States — Site recruitment status not specified in the registry data
Central Florida Kidney Specialists Oakwater — Orlando, Florida, 32806, United States — Site recruitment status not specified in the registry data
Bolanos Clinical Research — Pembroke Pines, Florida, 33026, United States — Site recruitment status not specified in the registry data
Progressive Medical Research — Port Orange, Florida, 32127, United States — Site recruitment status not specified in the registry data

Study details

Start date: January 9, 2026
Primary completion date: October 13, 2028
First posted: December 9, 2025

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07271186
Registry last updated: September 11, 2026
QualifiedStudies registry data refreshed: September 21, 2026

View NCT07271186 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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