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Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies

NCT ID: NCT07177352
Registry status: Recruiting
Study type: Interventional
Phase: Phase 3
Sponsor: Hoffmann-La Roche
Conditions: Alzheimers Disease

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Master Screening Study to Determine Individuals With Potential Trial Eligibility for Alzheimer's Disease Studies as Assessed by Biomarker Status and Cognition

Enrollment: 80000 participants (Estimated).

What is being studied

Other: No Intervention

Who may be eligible

Ages: 50 Years to 90 Years
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Ability and willingness to participate in an interventional clinical study, including meeting key eligibility criteria of linked interventional Roche AD studies (e.g., specific age ranges) * Ability and willingness to receive information about potential eligibility in an associated interventional Roche AD study Exclusion Criteria: * Dependency in basic activities of daily living (bADLs) due to cognitive impairment * Visual or auditory impairment that would prevent them from performing the cognitive assessments (eyeglasses and hearing aids are permitted) * Any self-reported evidence or known diagnosis of a neurological or neurodegenerative condition that may lead to cognitive impairment other than AD * History of severe, clinically significant central nervous system trauma * Any serious medical condition that precludes a participant's safe participation and completion of a clinical study * For participants with a clinical diagnosis of MCI or mild AD: Previous AD diagnosis based on biomarker confirmation with an approved or validated rule in method (e.g., amyloid PET or cerebrospinal fluid, blood biomarker) is exclusionary

Study locations

229 study locations are listed.

Recruiting site status is explicitly provided for 229 locations; 203 are listed as Recruiting.

Countries: Argentina, Australia, Brazil, Canada, Chile, China, Denmark, Italy, Japan, Poland, Puerto Rico, South Korea, Spain, Taiwan, United States

Santa Fe Province, Argentina: 1
New South Wales, Australia: 4
South Australia, Australia: 2
Victoria, Australia: 4
Paraná, Brazil: 2
Rio Grande do Sul, Brazil: 3
Santa Catarina, Brazil: 1
São Paulo, Brazil: 2
British Columbia, Canada: 3
Nova Scotia, Canada: 1
Ontario, Canada: 10
Quebec, Canada: 2
Beijing Municipality, China: 1
Jiangsu, China: 1
Campania, Italy: 1
Lazio, Italy: 4
Liguria, Italy: 1
Lombardy, Italy: 2
Sicily, Italy: 1
Umbria, Italy: 1
Alicante, Spain: 1
Barcelona, Spain: 2
Madrid, Spain: 1
Alabama, United States: 1
Arizona, United States: 2
California, United States: 8
Connecticut, United States: 1
Florida, United States: 13
Georgia, United States: 5
Hawaii, United States: 1

Sample of listed locations

INECO Neurociencias Orono — Rosario, Santa Fe Province, S2000DTC, Argentina — Recruiting
Hospital Italiano de Buenos Aires — Buenos Aires, C1181ACH, Argentina — Recruiting
Fundacion Scherbovsky — Mendoza, 5500, Argentina — Recruiting
Royal Prince Alfred Hospital — Camperdown, New South Wales, 2050, Australia — Recruiting
St Vincent's Hospital Sydney — Darlinghurst, New South Wales, 2010, Australia — Recruiting
Southern Neurology — Kogarah, New South Wales, 2217, Australia — Recruiting
KaRa Institute of Neurological Diseases — Macquarie Park, New South Wales, 2113, Australia — Recruiting
Flinders Medical Centre — Bedford Park, South Australia, 5042, Australia — Recruiting
Queen Elizabeth Hospital — Woodville, South Australia, 5011, Australia — Recruiting
Box Hill Hospital — Box Hill, Victoria, 3128, Australia — Recruiting
Heidelberg Repatriation Hospital — Heidelberg, Victoria, 3081, Australia — Recruiting
Alfred Health — Melbourne, Victoria, 3004, Australia — Recruiting
Royal Melbourne Hospital — Parkville, Victoria, 3050, Australia — Recruiting
Instituto de Neurologia de Curitiba — Curitiba, Paraná, 81210-310, Brazil — Recruiting
Clinica Clinilive ltda — Maringá, Paraná, 87013-250, Brazil — Recruiting
Hospital das Clinicas - UFRGS — Porto Alegre, Rio Grande do Sul, 90035-903, Brazil — Recruiting
Hospital Moinhos de Vento — Porto Alegre, Rio Grande do Sul, 90035-001, Brazil — Recruiting
Instituto do Cerebro do Rio Grande do Sul — Porto Alegre, Rio Grande do Sul, 90610-000, Brazil — Recruiting
Clinica Neurologica — Joinville, Santa Catarina, 89202-190, Brazil — Recruiting
Centro Multidisciplinar de Estudos Clínicos - CEMEC*X* — São Bernardo do Campo, São Paulo, 09715-090, Brazil — Recruiting
Centro de Pesquisas Clinicas - CPCLIN — São Paulo, São Paulo, 01244-030, Brazil — Recruiting
Kelowna Health and Memory Centre Ltd. — Kelowna, British Columbia, V1Y 5A8, Canada — Recruiting
Okanagan Clinical Trials — Kelowna, British Columbia, V1Y 1Z9, Canada — Recruiting
Richmond Clinical Trials — Richmond, British Columbia, V6V 2L1, Canada — Recruiting
Centricity Research — Halifax, Nova Scotia, B3S 1N2, Canada — Recruiting

Study details

Start date: July 2, 2025
Primary completion date: July 31, 2035
Completion date: July 31, 2035
First posted: September 17, 2025

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07177352
Registry last updated: September 21, 2026
QualifiedStudies registry data refreshed: September 28, 2026
QualifiedStudies record fetched: September 28, 2026

View NCT07177352 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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