Are clinical trials safe?

Yes. Every study on QualifiedStudies is reviewed and approved by an Institutional Review Board (IRB) and conducted under FDA regulations. Research sites are HIPAA-covered entities, and you can withdraw at any time for any reason.

Do I get paid to participate in a clinical trial?

Most studies offer compensation for your time and travel. The amount varies by study length and visit schedule, and is disclosed up front before you enroll.

Is my health information kept private?

Yes. Your information is encrypted, never sold, and only shared with the specific research site you choose to apply to. Our handling of your data is governed by our Consumer Health Data Privacy Policy; the research sites you're matched with are HIPAA-covered entities.

How do I qualify for a clinical trial?

Take our free 60-second eligibility quiz. Enter your ZIP code, condition, and a few health details, and we'll match you with research sites near you that are actively enrolling participants.

A Clinical Trial to Evaluate Efficacy and Safety of Xeomin® Injections for Preventing Chronic Migraine

NCT ID: NCT07018713
Registry status: Recruiting
Study type: Interventional
Phase: Phase 3
Sponsor: Merz Therapeutics GmbH
Conditions: Chronic Migraine

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Phase 3, Randomized, Double-blind, Placebo-controlled, Multicenter, Clinical Trial With Extension Period to Evaluate the Efficacy and Safety of Xeomin® Injections for the Prevention of Chronic Migraine

Enrollment: 780 participants (Estimated).

What is being studied

Intervention: Amino Acids, Peptides, and Proteins
Intervention: Bacterial Proteins
Intervention: Bacterial Toxins
Intervention: Biological Factors
Intervention: Botulinum Toxins
Intervention: Botulinum Toxins, Type A
Intervention: Endopeptidases
Intervention: Enzymes
Intervention: Enzymes and Coenzymes
Intervention: Hydrolases
Intervention: incobotulinumtoxinA
Intervention: Metalloendopeptidases
Intervention: Metalloproteases
Intervention: Peptide Hydrolases
Drug: Placebo
Intervention: Proteins
Intervention: Toxins, Biological
Drug: Xeomin

Who may be eligible

Ages: 18 Years to no maximum
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Participant has a diagnosis of CM with or without aura according to the International Classification of Headache Disorders Edition 3 criteria for ≥ 12 months and is able to distinguish migraine headaches from all other types of headaches; * Participant age \< 50 years at the time of migraine onset; * Participant meeting the following headache and migraine day criteria in each of the 3 months prior to screening: history of ≥ 15 headache days per month and history of ≥ 8 migraine days per month; and * During the last 28 days of the screening period, participant experiencing: ≥ 15 headache days and ≥ 8 migraine days that qualify as such per the headache diary. Exclusion Criteria: * Diagnosis of other primary headache types, except tension-type headache, which is permitted; * Diagnosis of aura without headache, migraine with brainstem aura, hemicrania continua, hypnic headache, hemiplegic migraine, retinal migraine, persistent aura without infarction, migraine aura-triggered seizure, or previous migrainous infarction; * Diagnosis of secondary headache types, except medication overuse headache, which is permitted; * Currently taking \> 1 prescribed drug for the preventive treatment of migraine; * Discontinuation of anti-calcitonin gene-related peptide (CGRP) / anti-CGRP receptor monoclonal antibody treatment less than 5 months prior to screening.

Study locations

111 study locations are listed.

Recruiting site status is explicitly provided for 111 locations; 111 are listed as Recruiting.

Countries: Austria, Canada, Czechia, Denmark, France, Germany, Italy, Poland, Slovakia, Spain, Switzerland, United Kingdom, United States

Arizona, United States: 2
Arkansas, United States: 1
California, United States: 4
Connecticut, United States: 3
Florida, United States: 7
Georgia, United States: 1
Hawaii, United States: 1
Kansas, United States: 1
Louisiana, United States: 2
Maryland, United States: 1
Massachusetts, United States: 2
Michigan, United States: 2
Minnesota, United States: 1
Missouri, United States: 1
Nebraska, United States: 1
New York, United States: 6
Ohio, United States: 3
Oklahoma, United States: 1
Pennsylvania, United States: 1
South Carolina, United States: 1
Texas, United States: 2
Virginia, United States: 2
Washington, United States: 1
Wisconsin, United States: 1

Sample of listed locations

Medical University of Innsbruck, Merz Investigational Site #0430043 — Innsbruck, 6020, Austria — Recruiting
Klinikum Klagenfurt Am Wörthersee, Merz Investigational Site #0430042 — Klagenfurt, 9020, Austria — Recruiting
Genge Partners Inc., Merz Investigational Site #0010525 — Montreal, H4A 3T2, Canada — Recruiting
CaRe Clinic, Merz Investigational Site #0010504 — Red Deer, T4P 1K4, Canada — Recruiting
Pratia Brno, Merz Investigational Site #4200053 — Brno, 602 00, Czechia — Recruiting
Fakultní nemocnice Hradec Králové, Merz Investigational Site #4200056 — Hradec Králové, 500 05, Czechia — Recruiting
Axon Clinical, Merz Investigational Site #4200051 — Prague, 150 00, Czechia — Recruiting
CLINTRIAL, Merz Investigational Site #4200052 — Prague, 100 00, Czechia — Recruiting
Neuropsychiatrie, Merz Investigational Site #4200054 — Prague, 160 00, Czechia — Recruiting
Rigshospitalet-Glostrup, Merz Investigational Site #0450006 — Glostrup Municipality, 2600, Denmark — Recruiting
CHU Clermont Ferrand, Merz Investigational Site #0330026 — Clermont-Ferrand, 63000, France — Recruiting
Centre Hospitalier Universitaire Grenoble Alpes, Merz Investigational Site #0330069 — La Tronche, 38700, France — Recruiting
CHU Nantes, Merz Investigational Site #0330068 — Nantes, 44093, France — Recruiting
Charité - Universitätsmedizin Berlin, Merz Investigational Site #0490398 — Berlin, 10117, Germany — Recruiting
Kopfschmerzzentrum Frankfurt, Merz Investigational Site #0490394 — Frankfurt, 65929, Germany — Recruiting
Universitätsmedizin Greifswald, Merz Investigational Site #0490397 — Greifswald, 17475, Germany — Recruiting
Vitos Orthopädische Klinik Kassel, Merz Investigational Site #0490396 — Kassel, 34131, Germany — Recruiting
Schmerzklinik Kiel GmbH, Merz Investigational Site #0490395 — Kiel, 24149, Germany — Recruiting
Azienda Ospedaliera Universitaria Careggi, Merz Investigational Site #0390023 — Florence, 50134, Italy — Recruiting
Istituto Auxologico Italiano, Merz Investigational Site #0390024 — Milan, 20149, Italy — Recruiting
Ospedale San Raffaele, Merz Investigational Site #0390027 — Milan, 20132, Italy — Recruiting
Fondazione Istituto Neurologico Nazionale Casimiro Mondino, Merz Investigational Site #0390025 — Pavia, 27100, Italy — Recruiting
IRCCS San Raffaele Roma, Merz Investigational Site #0390026 — Roma, 00166, Italy — Recruiting
AthleticoMed, Merz Investigational Site #0480127 — Bydgoszcz, 85-752, Poland — Recruiting
Centrum Medyczne Neuromed, Merz Investigational Site #0480117 — Bydgoszcz, 85-163, Poland — Recruiting

Study details

Start date: August 21, 2025
Primary completion date: October 1, 2027
Completion date: March 1, 2028
First posted: June 12, 2025

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07018713
Registry last updated: September 25, 2026
QualifiedStudies registry data refreshed: October 5, 2026
QualifiedStudies record fetched: October 5, 2026

View NCT07018713 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Migraines studies | Clinical trial FAQ