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RE104 Safety and Efficacy Study in Adjustment Disorder in Cancer and Other Medical Illnesses

NCT ID: NCT07002034
Registry status: Recruiting
Study type: Not specified in the registry data
Phase: Phase 2
Sponsor: Reunion Neuroscience Inc

Overview

ClinicalTrials.gov lists this study as Recruiting.

Enrollment: 100 participants (Estimated).

What is being studied

No interventions are listed in the registry data.

Who may be eligible

Ages: Not specified in the registry data
Sex: Not specified in the registry data
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Has a ≥4 week history of AjD as defined by DSM-5-TR with either depressed mood, or mixed anxiety and depressed mood confirmed by clinical interview with evidence that the AjD was instigated by one of the following medical illnesses (e.g., diagnosis, impact, management, recurrence, prognosis): Cancer, ALS, MS, PD or IPF * Is sufficiently ambulatory and capable of self care as necessary to complete study procedures * Has normal cognitive function * Is on stable use of antidepressants or psychotherapy, or is willing to delay use until the end of study * If female is not pregnant or planning to become pregnant. If male is not planning to make a partner pregnant * Is willing and able to comply with the conditions and requirements of the study Exclusion Criteria: * Has a significant risk of suicide * Has active or medical history of bipolar disorder, schizophrenia, schizoaffective disorder, psychotic disorder and/or borderline personality disorder, or first-degree family history of psychosis or bipolar disorder * Has active or a history of central nervous system malignancy * Has other medically significant conditions rendering unsuitability for the study * Has used or will need to use prohibited medications or therapies * Has a known sensitivity or intolerance to study intervention or potential rescue medications

Study locations

32 study locations are listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: United States

Alabama, United States: 1
Arizona, United States: 1
California, United States: 2
Colorado, United States: 1
Florida, United States: 1
Georgia, United States: 1
Hawaii, United States: 1
Illinois, United States: 2
Kansas, United States: 1
Louisiana, United States: 1
Maryland, United States: 2
Massachusetts, United States: 2
Michigan, United States: 2
Nebraska, United States: 1
New Mexico, United States: 1
New York, United States: 2
North Carolina, United States: 1
Ohio, United States: 2
Pennsylvania, United States: 1
Tennessee, United States: 1
Texas, United States: 1
Utah, United States: 1
Virginia, United States: 1
Washington, United States: 1
Wisconsin, United States: 1

Sample of listed locations

UAB, Psychiatry and Behavioral Neurology — Birmingham, Alabama, 35209, United States — Site recruitment status not specified in the registry data
University of Arizona — Tucson, Arizona, 85724, United States — Site recruitment status not specified in the registry data
Kadima Neuropsychiatry Institute — San Diego, California, 92037, United States — Site recruitment status not specified in the registry data
Providence Medical Foundation — Santa Rosa, California, 95403, United States — Site recruitment status not specified in the registry data
University of Colorado — Aurora, Colorado, 80045, United States — Site recruitment status not specified in the registry data
University of South Florida, Department of Psychiatry and Behavioral Neuroscience — Tampa, Florida, 33613, United States — Site recruitment status not specified in the registry data
Emory University — Atlanta, Georgia, 30329, United States — Site recruitment status not specified in the registry data
Hawaii Pacific Neuroscience — Honolulu, Hawaii, 96817, United States — Site recruitment status not specified in the registry data
Rush University Medical Center — Chicago, Illinois, 60612, United States — Site recruitment status not specified in the registry data
University of Chicago Medical Center — Chicago, Illinois, 60637, United States — Site recruitment status not specified in the registry data
The University of Kansas Medical Center — Kansas City, Kansas, 66160, United States — Site recruitment status not specified in the registry data
LSU Health Shreveport — Shreveport, Louisiana, 71103, United States — Site recruitment status not specified in the registry data
Sunstone Therapies, PC — Rockville, Maryland, 20850, United States — Site recruitment status not specified in the registry data
Sheppard Pratt — Towson, Maryland, 21204, United States — Site recruitment status not specified in the registry data
Dana Farber Cancer Institute — Boston, Massachusetts, 02215, United States — Site recruitment status not specified in the registry data
University of Massachusetts Chan Medical Center — Worcester, Massachusetts, 01655, United States — Site recruitment status not specified in the registry data
University of Michigan — Ann Arbor, Michigan, 48109, United States — Site recruitment status not specified in the registry data
Henry Ford Health — Novi, Michigan, 48377, United States — Site recruitment status not specified in the registry data
University of Nebraska Medical Center — Omaha, Nebraska, 68198, United States — Site recruitment status not specified in the registry data
University of New Mexico, School of Medicine — Albuquerque, New Mexico, 87131, United States — Site recruitment status not specified in the registry data
Roswell Park Center Institute — Buffalo, New York, 14263, United States — Site recruitment status not specified in the registry data
NYU Langone Health — New York, New York, 10016, United States — Site recruitment status not specified in the registry data
University of North Carolina at Chapel Hill — Chapel Hill, North Carolina, 27514, United States — Site recruitment status not specified in the registry data
Cleveland Clinic — Cleveland, Ohio, 44113, United States — Site recruitment status not specified in the registry data
The Ohio State University, Department of Psychiatry — Columbus, Ohio, 43210, United States — Site recruitment status not specified in the registry data

Study details

Start date: July 30, 2025
Primary completion date: November 1, 2026
First posted: June 3, 2025

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT07002034
Registry last updated: September 15, 2026
QualifiedStudies registry data refreshed: September 21, 2026

View NCT07002034 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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