Differences in Mechanistic Measures (Oxytocin and Cortisol) of Therapeutic Alliance Between A Talk-Based Therapy and Soft-Tissue Mobilization in Individuals With Chronic Spinal Pain

NCT ID
NCT06987786
Registry status
Not yet recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Duke University
Conditions
Low Back Pain, Neck Pain, Spine

Overview

ClinicalTrials.gov lists this study as Not yet recruiting.

Enrollment: 25 participants (Estimated).

What is being studied

  • Intervention: Complementary Therapies
  • Intervention: Massage
  • Other: Massage
  • Intervention: Musculoskeletal Manipulations
  • Intervention: Physical Therapy Modalities
  • Intervention: Rehabilitation
  • Other: Talk-based therapy
  • Intervention: Therapeutics
  • Intervention: Therapy, Soft Tissue

Who may be eligible

Ages
18 Years to no maximum
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria include: * Individuals with chronic spine pain (3 months or greater) (and); * who are 18 years of age and older (and) * who experience persistent pain of ≥3 on a 10-point scale for the majority of days during the previous 3-months (The study operationally defines chronic pain using the International Association of the Study of Pain (IASP) pragmatic criteria of pain lasting for 3 months or more that cannot be attributed to another diagnosis or condition). \- Exclusion Criteria include: * Participants with medical conditions that may influence hormone levels during the study (e.g., Cushing's Syndrome, Addison's Disease, etc.) (or), * Use of medications (e.g., steroids, antidepressants, or hormonal treatments) that could influence the results (or) * Previously diagnosed conditions or factors known to affect cortisol or oxytocin levels, such as chronic stress disorders, hormonal imbalances, or pregnancy. (After obtaining consent and prior to treatment), the study will screen for potential massage contraindications or other clinical safety considerations and will exclude if: * participants have infection, skin lesions, (or) * Fractures in the region of the massage

Study locations

1 study location is listed.

Site recruitment status is not specified in the registry data for these locations.

Countries: United States

  • North Carolina, United States: 1

Sample of listed locations

  • CORE 2200 West Main Street — Durham, North Carolina, 27705, United States — Site recruitment status not specified in the registry data

Study details

Start date
December 1, 2026
Primary completion date
June 30, 2027
Completion date
October 30, 2027
First posted
May 23, 2025

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT06987786
Registry last updated
October 16, 2026
QualifiedStudies registry data refreshed
October 19, 2026
QualifiedStudies record fetched
October 19, 2026

View NCT06987786 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Neck Pain studies | Clinical trial FAQ