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A Study to Evaluate Different Targeted Therapies for Patients With Rheumatoid Arthritis

NCT ID: NCT06972446
Registry status: Recruiting
Study type: Interventional
Phase: Phase 2
Sponsor: AbbVie
Conditions: Rheumatoid Arthritis

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Phase 2, Multicenter, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderately to Severely Active Rheumatoid Arthritis

Enrollment: 180 participants (Estimated).

What is being studied

Drug: ABBV-701
Drug: ABBV-848
Drug: ABBV-8736
Intervention: Adalimumab
Drug: Adalimumab
Intervention: Amino Acids, Peptides, and Proteins
Intervention: Antibodies
Intervention: Antibodies, Monoclonal
Intervention: Antibodies, Monoclonal, Humanized
Intervention: Blood Proteins
Intervention: Globulins
Intervention: Immunoglobulins
Intervention: Immunoproteins
Intervention: lutikizumab
Drug: Lutikizumab
Drug: Placebo
Intervention: Proteins
Drug: Ravagalimab
Intervention: Serum Globulins

Who may be eligible

Ages: 18 Years to no maximum
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * At any time prior to the Screening Visit, participant must have been treated for \> or = 3 months with at least 1 b/tsDMARD therapy but continued to exhibit active RA, or had to discontinue due to intolerability or toxicity, irrespective of treatment duration. The maximum cap for prior use of b/tsDMARD is 2. * Participant must be on a stable dose of methotrexate (MTX) Exclusion Criteria: * Participant is taking nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen/paracetamol, low-potency opioids (tramadol, codeine, hydrocodone, alone or in combination with acetaminophen), oral corticosteroids (equivalent to ≤ 10 mg/day of prednisone), or inhaled corticosteroids for stable medical conditions unless they have been on stable doses for ≥ 1 week prior to Baseline Visit. * History of any arthritis with onset prior to age 17 years or current diagnosis of inflammatory joint disease other than rheumatoid arthritis. Sub-study 6 specific: * Prior exposure to any Interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitor or degrader. * Prior exposure to any biologic and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs).

Study locations

96 study locations are listed.

Recruiting site status is explicitly provided for 96 locations; 96 are listed as Recruiting.

Countries: Canada, Czechia, Germany, Hungary, Poland, Puerto Rico, Serbia, Slovakia, South Korea, Spain, Taiwan, United States

Alberta, Canada: 1
Quebec, Canada: 1
Saskatchewan, Canada: 1
Moravian-Silesian Region, Czechia: 1
Hesse, Germany: 1
North Rhine-Westphalia, Germany: 2
Csongrád megye, Hungary: 1
Fejér, Hungary: 2
Kuyavian-Pomeranian Voivodeship, Poland: 2
Lesser Poland Voivodeship, Poland: 2
Masovian Voivodeship, Poland: 1
Warmian-Masurian Voivodeship, Poland: 2
Beograd, Serbia: 2
Juznobacki Okrug, Serbia: 2
Žilina Region, Slovakia: 1
Chungcheongnam-do, South Korea: 1
Gyeonggido, South Korea: 1
Seoul Teugbyeolsi, South Korea: 2
Barcelona, Spain: 1
Sevilla, Spain: 1
Vizcaya, Spain: 1
Arizona, United States: 1
Arkansas, United States: 1
California, United States: 6
Colorado, United States: 1
Florida, United States: 10
Illinois, United States: 5
Louisiana, United States: 1
Michigan, United States: 1
New Jersey, United States: 1

Sample of listed locations

Care Clinic - Calgary /ID# 274405 — Calgary, Alberta, T2N 4L7, Canada — Recruiting
Centre Hospitalier Universite De Sherbrooke - Hotel-Dieu Hospital /ID# 273711 — Sherbrooke, Quebec, J1G 2E8, Canada — Recruiting
Dr. Latha Naik Medical Professional Corporation /ID# 274403 — Saskatoon, Saskatchewan, S7H 0P4, Canada — Recruiting
L.K.N. Arthrocentrum /ID# 271932 — Hlučín, Moravian-Silesian Region, 748 01, Czechia — Recruiting
MEDICAL PLUS Research s.r.o /ID# 271926 — Uherské Hradiště, 686 01, Czechia — Recruiting
PV Medical Services /ID# 271934 — Zlín, 760 01, Czechia — Recruiting
Rheumateam Lahn-Dill-Siegerland /ID# 274858 — Wetzlar, Hesse, 35578, Germany — Recruiting
Universitaetsklinikum Bonn /ID# 272808 — Bonn, North Rhine-Westphalia, 53127, Germany — Recruiting
Krankenhaus Porz Am Rhein /ID# 272903 — Cologne, North Rhine-Westphalia, 51149, Germany — Recruiting
Mvz Rheuma /ID# 272795 — Hamburg, 20095, Germany — Recruiting
Szegedi Tudomanyegyetem /ID# 272865 — Szeged, Csongrád megye, 6720, Hungary — Recruiting
Complex Rendelo Med Zrt. /ID# 272859 — Székesfehérvár, Fejér, 8000, Hungary — Recruiting
Vital-Medicina /ID# 272858 — Veszprém, Fejér, 8200, Hungary — Recruiting
Qualiclinic /ID# 281259 — Budapest, 1134, Hungary — Recruiting
Revita Reumatologiai Rendelo (Revita Kft.) /ID# 281247 — Budapest, 1027, Hungary — Recruiting
Semmelweis Egyetem Reumatologiai es Immunologiai Klinika /ID# 273212 — Budapest, 1023, Hungary — Recruiting
Medicover Integrated Clinical Services - Bydgoszcz (SMO/Network/Consortium) /ID# 272975 — Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-068, Poland — Recruiting
Szpital Uniwersytecki Nr 2 Im. Dr Jana Biziela W Bydgoszczy /ID# 281180 — Bydgoszcz, Kuyavian-Pomeranian Voivodeship, 85-168, Poland — Recruiting
Centrum Nowoczesnych Terapii Dobry Lekarz sp.z.o.o. /ID# 281209 — Krakow, Lesser Poland Voivodeship, 31-011, Poland — Recruiting
Malopolskie Centrum Kliniczne /ID# 272965 — Krakow, Lesser Poland Voivodeship, 30-149, Poland — Recruiting
Centrum Medyczne Reuma Park /ID# 272968 — Warsaw, Masovian Voivodeship, 02-665, Poland — Recruiting
Centrum Kliniczno-Badawcze J.Brzezicki, B. Gornikiewicz-Brzezicka Lekarze Spolka /ID# 272966 — Elblag, Warmian-Masurian Voivodeship, 82-300, Poland — Recruiting
Etyka Osrodek Badan Klinicznych /ID# 272974 — Olsztyn, Warmian-Masurian Voivodeship, 10-117, Poland — Recruiting
Clinical Research Investigator Group /ID# 274821 — Bayamón, 00960, Puerto Rico — Recruiting
Centro Reumatologico De Caguas /ID# 277918 — Caguas, 00725, Puerto Rico — Recruiting

Study details

Start date: June 20, 2025
Primary completion date: February 1, 2027
Completion date: November 1, 2027
First posted: May 15, 2025

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT06972446
Registry last updated: September 22, 2026
QualifiedStudies registry data refreshed: October 2, 2026
QualifiedStudies record fetched: October 2, 2026

View NCT06972446 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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