Perioperative Colchicine for TKA
- NCT ID
- NCT06936709
- Registry status
- Not yet recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Sponsor
- Geisinger Clinic
- Conditions
- Osteoarthritis of Knee, Perioperative Pain Control, Recovery Following Primary Total Knee Arthroplasty
Overview
ClinicalTrials.gov lists this study as Not yet recruiting.
Official title: Effect of Colchicine in the Perioperative Period on Reducing Post-Operative Pain in Total Knee Arthroplasty
Enrollment: 75 participants (Estimated).
What is being studied
- Intervention: Alkaloids
- Intervention: Colchicine
- Drug: Colchicine 1.8 mg (loading dose) + Dextrose Oral Placebo
- Drug: Colchicine 1.8 mg + 0.6 mg
- Drug: Dextrose Oral Placebo
- Intervention: Heterocyclic Compounds
Who may be eligible
- Ages
- 18 Years to no maximum
- Sex
- All
- Healthy volunteers accepted
- No
ClinicalTrials.gov lists the following eligibility criteria.
Inclusion Criteria:
* Patients 18 years or older undergoing elective total knee arthroplasty for osteoarthritis.
Exclusion Criteria:
* Subject has impaired hepatic function (Child-Pugh Class \>B)
* Subject has impaired renal function (GFR \< 60 ml/min/1.73 m2)
* Subject has known adverse reaction to colchicine
* Subject has chronic opioid use (Filled opioid medication twice within 6 months of surgical date)
* Subject is pregnant or expecting to become pregnant during the time of the study associated with colchicine exposure (postoperative days 0-3)
* Subject is unable to provide informed consent
* Subject is actively prescribed medication that interact with colchicine in a manner that would increase the risk of colchicine toxicity, i.e.:
* Antifungals: Ketoconazole, itraconazole, fluconazole, etc…
* Macrolides : Clarithromycin, erythromycin
* HIV protease : Ritonavir, Atazanavir, saquinavir, etc...
* Ca2+: Verapamil and Diltiazem
* Cyclosporine
* Danazol
* Amiodorone
* Quinidine
* Anti-hepaciviral combinations
* Grapefruit juice
* Statins: atorvastatin, lovastatin, simvastatin, etc…
* Gemfibrozil and other fibrates
* Digoxin
Study locations
No study locations are listed in the registry data.
Study details
- Start date
- December 1, 2026
- Primary completion date
- January 1, 2027
- Completion date
- March 1, 2027
- First posted
- April 20, 2025
- Collaborators
- St. Luke's Hospital, Kansas City, Missouri
Source and update information
- Source
- ClinicalTrials.gov
- NCT ID
- NCT06936709
- Registry last updated
- September 3, 2026
- QualifiedStudies registry data refreshed
- October 5, 2026
- QualifiedStudies record fetched
- October 5, 2026
View NCT06936709 on ClinicalTrials.gov
Trial information can change. Confirm current study details with the study team or the registry.
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