Radio- KO Radiotherapy for Knee Osteoarthritis Clinical Trial

NCT ID
NCT06887829
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Mayo Clinic
Conditions
Osteoarthritis, Knee

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Low-dose RADIOtherapy for Knee Osteoarthritis (RADIO-KO): Protocol for a Single-center, Sham-controlled, Randomized Clinical Trial

Enrollment: 128 participants (Estimated).

What is being studied

  • Radiation: Low dose radiotherapy
  • Intervention: Radiotherapy
  • Other: Sham comparator
  • Intervention: Therapeutics

Who may be eligible

Ages
50 Years to 100 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: Age 50-100 years with a Mayo Clinic Rochester primary care provider At least moderate constant (ICOAP item A1) or intermittent (ICOAP item B6) pain Diagnosis of primary knee OA (ICD-10 M17.x) without recurrent acute inflammatory flares Joint-line tenderness on examination co-localizes with the reported pain and without a primary extra-articular pain generator Radiographic KL grade 2-3 within the preceding year Ability to complete electronic surveys Exclusion Criteria: Pregnancy or childbearing potential without surgical sterilization Recent knee trauma is causing the current pain History of inflammatory arthritis or hemarthrosis Symptomatic hip OA KL grade 1 or 4 Uncontrolled psychiatric illness Prior ipsilateral intra-articular knee surgery Corticosteroid injection within 3 months or hyaluronic acid injection within 6 months in the ipsilateral knee (or 1 month if no sustained improvement after either) Fibromyalgia Active malignancy requiring treatment Regular current use of opioids, platelet-rich plasma, or acupuncture use for the knee

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • Minnesota, United States: 1

Sample of listed locations

  • Mayo Clinic — Rochester, Minnesota, 55905, United States — Recruiting

Study details

Start date
June 4, 2025
Primary completion date
June 28, 2027
Completion date
October 29, 2027
First posted
March 20, 2025

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT06887829
Registry last updated
September 2, 2026
QualifiedStudies registry data refreshed
September 24, 2026
QualifiedStudies record fetched
September 24, 2026

View NCT06887829 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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