A Study to Evaluate the Drug Levels, Efficacy, and Safety of Deucravacitinib (BMS-986165) in Pediatric Participants With Juvenile Psoriatic Arthritis

NCT ID
NCT06869551
Registry status
Recruiting
Study type
Interventional
Phase
Phase 3
Sponsor
Bristol-Myers Squibb
Conditions
Juvenile Psoriatic Arthritis

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Phase 3, Multicenter, Double-blind, Placebo-controlled, Randomized Withdrawal Trial to Evaluate the Efficacy, Safety, and Pharmacokinetics of Deucravacitinib in Children and Adolescents From 5 to Less Than 18 Years of Age With Active Juvenile Psoriatic Arthritis

Enrollment: 60 participants (Estimated).

What is being studied

  • Intervention: deucravacitinib
  • Drug: Deucravacitinib
  • Other: Placebo

Who may be eligible

Ages
5 Years to 17 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria * Participants must have been diagnosed with Juvenile Psoriatic Arthritis (JPsA). * Participants must have at least three joints that are affected by arthritis. * Participants must have tried at least one type of medicine for JPsA for at least three months, but it didn't work well or caused problems. Exclusion Criteria * Participants must not have been diagnosed with JPsA before 5 years of age. * Participants must not have other types of Juvenile Idiopathic Arthritis (JIA) that aren't JPsA, * Participants must not have a history of chronic eye inflammation (uveitis), or were diagnosed with uveitis within the last three months. * Other protocol-defined Inclusion/Exclusion criteria apply.

Study locations

48 study locations are listed.

Recruiting site status is explicitly provided for 48 locations; 29 are listed as Recruiting.

Countries: Brazil, Bulgaria, China, Czechia, Germany, Italy, Puerto Rico, Romania, Spain, Turkey (Türkiye), United States

  • Ceará, Brazil: 1
  • Mato Grosso, Brazil: 1
  • Minas Gerais, Brazil: 1
  • Paraná, Brazil: 2
  • Pernambuco, Brazil: 1
  • Rio Grande do Sul, Brazil: 3
  • São Paulo-SP, Brazil: 1
  • Beijing Municipality, China: 2
  • Chongqing Municipality, China: 1
  • Guangdong, China: 1
  • Jiangsu, China: 1
  • Jilin, China: 1
  • Zhejiang, China: 1
  • Olomouc Region, Czechia: 1
  • Praha 5, Czechia: 1
  • Campania, Italy: 1
  • Tuscany, Italy: 1
  • Cluj, Romania: 1
  • Iaşi, Romania: 1
  • Vâlcea County, Romania: 1
  • Barcelona [Barcelona], Spain: 1
  • Madrid, Comunidad de, Spain: 1
  • Istanbul, Turkey (Türkiye): 1
  • California, United States: 1
  • Illinois, United States: 1
  • Indiana, United States: 1
  • New York, United States: 1
  • Ohio, United States: 2
  • Texas, United States: 1

Sample of listed locations

  • Centro de Oncologia Leonardo Da Vinci - ATO Terapias — Fortaleza, Ceará, 60140-025, Brazil — Recruiting
  • Santa Casa de Misericordia de Belo Horizonte — Belo Horizonte, Minas Gerais, 30150-221, Brazil — Recruiting
  • Hospital Pequeno Príncipe / Associação Hospitalar de Proteção à Infância — Curitiba, Paraná, 80250-060, Brazil — Recruiting
  • Hospital Das Clinicas Ufpe — Recife, Pernambuco, 50670-420, Brazil — Recruiting
  • LMK Serviços Médicos S/S — Porto Alegre, Rio Grande do Sul, 90480-000, Brazil — Recruiting
  • Hospital Lifeplus Litoral Norte — Xangri-lá, Rio Grande do Sul, 95588-000, Brazil — Recruiting
  • PSEG- Pesquisa Clínica — Vila Clementino, São Paulo-SP, 04038-002, Brazil — Recruiting
  • Santa Casa Instituto de Pesquisa — São Paulo, 01223-001, Brazil — Recruiting
  • University Multiprofile Hospital for Active Treatment "Sveti Georgi" EAD — Plovdiv, 4002, Bulgaria — Recruiting
  • Medical Center for Specialized Medical Care of Cardiovascular Diseases — Sofia, 1309, Bulgaria — Recruiting
  • The Children's Hospital of Chongqing Medical University — Chongqing, Chongqing Municipality, 400065, China — Recruiting
  • Guangzhou Women and Children's Medical Center — Guangzhou, Guangdong, 510000, China — Recruiting
  • Childrens Hospital of Nanjing Medical University — Nanjing, Jiangsu, 210008, China — Recruiting
  • The First Hospital of Jilin University — Changchun, Jilin, 130000, China — Recruiting
  • The Children's Hospital of Zhejiang University School of Medicine — Hangzhou, Zhejiang, 310057, China — Recruiting
  • Children's Hospital of Fudan University — Shanghai, 201102, China — Recruiting
  • Fakultni nemocnice Olomouc — Olomouc, Olomouc Region, 779 00, Czechia — Recruiting
  • Fakultni nemocnice v Motole — Prague, Praha 5, 150 06, Czechia — Recruiting
  • Kinderklinik des Uni-Klinikums Erlangen — Erlangen, 91054, Germany — Recruiting
  • Praxis Kinder- und Jugendrheumatologie Dr. Ivan Foeldvari — Hamburg, 22081, Germany — Recruiting
  • University of Naples Federico II — Naples, Campania, 80131, Italy — Recruiting
  • Azienda Ospedaliera Universitaria Meyer IRCCS — Florence, Tuscany, 50139, Italy — Recruiting
  • Spitalul Clinic de Urgenta pentru Copii Cluj-Napoca — Cluj-Napoca, Cluj, 400177, Romania — Recruiting
  • Sc Medaudio-Optica Srl — Râmnicu Vâlcea, Vâlcea County, 247065, Romania — Recruiting
  • Hospital Universitari Vall d'Hebron — Barcelona, Barcelona [Barcelona], 08035, Spain — Recruiting

Study details

Start date
March 13, 2025
Primary completion date
March 6, 2030
Completion date
March 4, 2031
First posted
March 11, 2025

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT06869551
Registry last updated
October 6, 2026
QualifiedStudies registry data refreshed
October 12, 2026
QualifiedStudies record fetched
October 12, 2026

View NCT06869551 on ClinicalTrials.gov

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