Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation

NCT ID
NCT06840262
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
M.D. Anderson Cancer Center
Conditions
Amputation

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Targeted Muscle Reinnervation (TMR) Versus Regenerative Peripheral Nerve Interfaces (RPNI) Versus the Combined Technique of TMR-RPNI to Reduce Chronic and Phantom Limb Pain in Oncologic Amputees: A Randomized Control Pilot Study

Enrollment: 54 participants (Estimated).

What is being studied

  • Other: Questionnaire Administration
  • Procedure: Regenerative Peripheral Nerve Interface Surgery
  • Procedure: Targeted Muscle Reinnervation

Who may be eligible

Ages
18 Years to no maximum
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * Patients greater than or equal to 18 years of age who are receiving an amputation for oncologic reasons * Patients with available mixed major nerves and donor motor nerves in the amputation stump or reconstructive tissue * Patients able to complete informed consent Exclusion Criteria: * Patients under 18 years of age * Patients unable to give consent * Patients receiving an amputation for non-oncologic purposes * Patients with amputations performed for immediate palliation (life expectancy less than 3 months), as this technique takes a minimum of 3-6 months for effect * Patients with multiple limb amputations * Patients receiving nerve management in a delayed fashion (patients who have previously received an amputation and present with neuroma)

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • Texas, United States: 1

Sample of listed locations

  • M D Anderson Cancer Center — Houston, Texas, 77030, United States — Recruiting

Study details

Start date
August 10, 2020
Primary completion date
February 2, 2027
Completion date
February 2, 2027
First posted
February 21, 2025

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT06840262
Registry last updated
September 21, 2026
QualifiedStudies registry data refreshed
September 28, 2026
QualifiedStudies record fetched
September 28, 2026

View NCT06840262 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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