Neuroimaging of Opioid Phase (OPAL)

NCT ID
NCT05905419
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Duke University
Conditions
Chronic Pain, Opioid Use

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Neurobiological Consequences of Long-Term Opioid Therapy in the Brain and Spinal Cord

Enrollment: 140 participants (Estimated).

What is being studied

  • Other: Opioid Phase

Who may be eligible

Ages
18 Years to no maximum
Sex
Female
Healthy volunteers accepted
Yes

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria for Healthy Controls: 1. female and ages 18+ 2. ability to read/understand English and give consent to participate 3. no current or history of chronic pain 4. not regularly taking any pain-relieving or mood-altering medications (per PI discretion) 5. absence of use of opioid medications Inclusion Criteria for Individuals with Chronic Pain: 1. female and ages 18 + 2. ability to read/understand English and give consent to participate 3. self-reported or physician diagnosis of fibromyalgia and/or chronic pain 4. current use of opioid medication(s) for inclusion in the opioid patient group -OR- absence of use of opioid medications for inclusion in the non-opioid patient group Exclusion Criteria (for both groups): 1. limited ability to participate fully in behavioral tasks, longitudinal follow-up 2. MRI contraindication 3. any factors that at the discretion of the investigators would adversely affect the participant or the integrity of the study 4. male

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • North Carolina, United States: 1

Sample of listed locations

  • Duke University Medical Center — Durham, North Carolina, 27710, United States — Recruiting

Study details

Start date
June 1, 2023
Primary completion date
June 30, 2027
Completion date
June 30, 2027
First posted
June 15, 2023
Collaborators
National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH)

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT05905419
Registry last updated
June 3, 2026
QualifiedStudies registry data refreshed
October 2, 2026
QualifiedStudies record fetched
October 2, 2026

View NCT05905419 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Clinical trial FAQ