The Role of Synovectomy in Pain Reduction Following Total Knee Arthroplasty

NCT ID
NCT05800457
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions
Osteoarthritis, Knee

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: The Role of Synovectomy in Pain Reduction Among Osteoarthritis Patients Following Total Knee Arthroplasty

Enrollment: 300 participants (Estimated).

What is being studied

  • Procedure: Partial synovectomy

Who may be eligible

Ages
41 Years to 80 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: 1. Males or females over the age of 40 diagnosed with knee osteoarthritis 2. Scheduled for first unilateral total knee arthroplasty 3. Moderate to severe (at least grade two) synovitis and synovial hyperplasia, as determined by ultrasound assessment 4. Referred to the Pre-Admission Clinic at University Hospital Exclusion Criteria: 1. Bilateral, uni-compartmental, or revision total knee arthroplasty 2. Osteoarthritis due to genetic syndromes (e.g., Ehlers-Danlos Syndrome, etc.) 3. Known inflammatory arthropathy, another rheumatic disease, or disease-modifying anti-rheumatic drug (DMARD) use (e.g. methotrexate, hydroxychloroquine, sulfasalazine, leflunomide, TNF inhibitors, etc.) - note: Gout is NOT an exclusion 4. Joint injection (steroid or viscosupplement) within 12 weeks of Pre-Admission Clinic appointment date 5. Cannot read, write, or understand English (printed instructions are provided in English only) 6. Any factors precluding patients from attending follow-up appointments (e.g., socio-economic limitations, distance from clinic, no access to home/cell phone, etc.). 7. Cognitive impairment or psychological problems that preclude the ability to understand instructions 8. Not able to follow up at routine standard of care post-operative visits

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: Canada

  • Ontario, Canada: 1

Sample of listed locations

  • London Health Sciences Centre - University Hospital — London, Ontario, N6A 5W9, Canada — Recruiting

Study details

Start date
November 20, 2023
Primary completion date
December 1, 2027
Completion date
December 1, 2027
First posted
April 5, 2023

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT05800457
Registry last updated
September 22, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT05800457 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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