Modulating Anxious Coping

NCT ID
NCT04824105
Registry status
Recruiting
Study type
Interventional
Phase
Not applicable
Sponsor
Medical University of South Carolina
Conditions
Anxiety Disorders

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Modeling and Modulating Mechanisms of Escape, Avoidance, and Approach in the Anxiety Disorder Spectrum

Enrollment: 80 participants (Estimated).

What is being studied

  • Intervention: Magnetic Field Therapy
  • Device: Repetitive Transcranial Magnetic Stimulation (rTMS)
  • Intervention: Therapeutics
  • Intervention: Transcranial Magnetic Stimulation

Who may be eligible

Ages
18 Years to 65 Years
Sex
All
Healthy volunteers accepted
No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: * 18 - 65 y.o. * Meets criteria for an anxiety disorder (Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder, Specific Phobia), posttraumatic stress disorder, obsessive- compulsive disorder, or current adjustment disorder with anxiety * Is currently seeking mental health treatment * Is able to read consent document and provide informed consent. * English is a first or primary fluent language. Exclusion Criteria: * Current alcohol or substance use disorder of more than mild severity (as defined by DSM-5 and determined using standardized self-report instruments) * Lifetime diagnosis of psychotic disorder or bipolar mania * Presence of neurological disorder that contraindicates TMS or neurophysiological recording: Seizure disorder Lifetime history of traumatic brain injury with loss of consciousness Neurodegenerative disorder (e.g., Alzheimer's Disease, Parkinson's Disease, Frontotemporal Dementia) * Presence of other medical disorder that would make it too uncomfortable to sit or lie still for long recording periods * Presence of standard contraindications for MRI or rTMS Metal in the body Currently pregnant Claustrophobia Significant sensitivity to noise Medical conditions or treatments that lower seizure threshold History of severe brain injury History of seizures/ epilepsy * Currently taking anticholinergic mediation, neuroleptic medication, or sedative/ hypnotic medication Note: SSRI, cholinesterase inhibitors or NMDA receptor antagonists are allowed if patient has been on a stable regimen of four weeks prior to enrollment * Currently taking chronic opiate medications or substances * Currently taking naltrexone

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • South Carolina, United States: 1

Sample of listed locations

  • Medical University of South Carolina — Charleston, South Carolina, 29425, United States — Recruiting

Study details

Start date
June 26, 2021
Primary completion date
August 31, 2026
Completion date
December 30, 2026
First posted
April 1, 2021
Collaborators
National Institute of Mental Health (NIMH)

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT04824105
Registry last updated
September 29, 2026
QualifiedStudies registry data refreshed
October 5, 2026
QualifiedStudies record fetched
October 5, 2026

View NCT04824105 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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