Are clinical trials safe?

Yes. Every study on QualifiedStudies is reviewed and approved by an Institutional Review Board (IRB) and conducted under FDA regulations. Research sites are HIPAA-covered entities, and you can withdraw at any time for any reason.

Do I get paid to participate in a clinical trial?

Most studies offer compensation for your time and travel. The amount varies by study length and visit schedule, and is disclosed up front before you enroll.

Is my health information kept private?

Yes. Your information is encrypted, never sold, and only shared with the specific research site you choose to apply to. Our handling of your data is governed by our Consumer Health Data Privacy Policy; the research sites you're matched with are HIPAA-covered entities.

How do I qualify for a clinical trial?

Take our free 60-second eligibility quiz. Enter your ZIP code, condition, and a few health details, and we'll match you with research sites near you that are actively enrolling participants.

RA-PRO PRAGMATIC TRIAL

NCT ID: NCT04692493
Registry status: Recruiting
Study type: Interventional
Phase: Phase 3
Sponsor: University of Alabama at Birmingham
Conditions: Rheumatoid Arthritis

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: A Real-World Comparative Effectiveness Trial of Treatment Strategies in Patients With Rheumatoid Arthritis: The RA-PRO Pragmatic Trial (RA-PROPR)

Enrollment: 924 participants (Estimated).

What is being studied

Drug: non-TNFi-biologic class
Drug: targeted synthetic DMARD class

Who may be eligible

Ages: 18 Years to no maximum
Sex: All
Healthy volunteers accepted: No

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: 1. Patients with active, disabling RA (CDAI ≥10 and HAQ ≥0.5) despite the use/experience of a TNFi-biologic OR discontinued the medication(s) due to intolerability or toxicity irrespective of treatment duration prior to the first dose of study drug ; 2. If receiving glucocorticoids (≤10 mg/day of prednisone of equivalent) or NSAIDs, on stable doses for ≥2 weeks prior to randomization; and 3. Insurance plan or patient assistance program allows access to at least 1 drug in each of the two treatment strategies, TNFi-biologic vs. tsDMARD.(TNFi-biologic and tsDMARD) will be obtained through insurance plan or a patient assistance program/plan. Participants will be allowed to continue their conventional synthetic DMARD (csDMARD) therapy if they had been using it for ≥ 3 months and on a stable dose for ≥ 4 weeks prior to the first dose of study drug. The following csDMARDs are allowed: methotrexate (MTX), sulfasalazine, hydroxychloroquine, and leflunomide Exclusion Criteria: 1. Prior treatment with more than three biologics, defined as TNFi-biologic or non-TNFi biologic 2. Prior treatment with targeted synthetic DMARD 3. Concomitant use of leflunomide, sulfasalazine, cyclosporine, or azathioprine within 2-months before randomization; 4. History of sensitivity to all 4 non-TNF-biologic or a targeted synthetic DMARD; 5. Glucocorticoid injection (intravenous, intramuscular, or intraarticular) within 1 month of study entry; 6. Live vaccine within 90 days of study entry; 7. Acute or chronic infections with parenteral antibiotics or hospitalization (including tuberculosis, bacterial sepsis; invasive fungal infections (such as histoplasmosis)) within 1 month or oral antibiotics within 2 weeks of study entry; 8. History of HIV or any opportunistic infection; 9. New York Heart Association Class III or IV heart failure; 10. Latent TB for which anti-tubercular treatment has not been started; 11. Untreated Hepatitis B or C infection; 12. History of deep venous thrombosis or pulmonary embolism; or 13. Pregnant or nursing women; or 14. History of herpes zoster or shingles in the previous 12 months and not subsequently vaccinated with herpes zoster vaccine.

Study locations

49 study locations are listed.

Recruiting site status is explicitly provided for 49 locations; 49 are listed as Recruiting.

Countries: Canada, United States

Ontario, Canada: 1
Alabama, United States: 3
Arizona, United States: 2
California, United States: 5
Florida, United States: 9
Georgia, United States: 1
Indiana, United States: 1
Maryland, United States: 1
Massachusetts, United States: 2
Michigan, United States: 1
Minnesota, United States: 2
New Mexico, United States: 2
New York, United States: 2
Ohio, United States: 4
Oregon, United States: 1
Pennsylvania, United States: 4
Tennessee, United States: 2
Texas, United States: 5
Virginia, United States: 1

Sample of listed locations

Mount Sinai Hospital (Canada) — Toronto, Ontario, M5T 3L9, Canada — Recruiting
East Alabama Arthritis Center PC — Auburn, Alabama, 36830, United States — Recruiting
Bendcare, LLC — Birmingham, Alabama, 35244, United States — Recruiting
University of Alabama at Birmingham — Birmingham, Alabama, 35294, United States — Recruiting
SunValley Arthritis Center, Ltd — Peoria, Arizona, 85381, United States — Recruiting
University of Arizona — Tucson, Arizona, 85724, United States — Recruiting
Pacific Arthritis Care Center — Los Angeles, California, 90045, United States — Recruiting
University of California, Los Angeles — Los Angeles, California, 90095, United States — Recruiting
Arthritis Medical Center — Nipomo, California, 93444, United States — Recruiting
Turlock Arthritis & Osteoporosis Center, — Turlock, California, 95382, United States — Recruiting
Center for Rheumatology Research — Woodland Hills, California, 91364, United States — Recruiting
George Munoz MD, PC — Aventura, Florida, 33180, United States — Recruiting
American Arthritis and Rheumatology Associates LLC — Clearwater, Florida, 33765, United States — Recruiting
CZ Rheumatology — Coral Springs, Florida, 33065, United States — Recruiting
American Arthritis and Rheumatology Associates LLC — Fort Lauderdale, Florida, 33309, United States — Recruiting
Mayo Clinic Jacksonville — Jacksonville, Florida, 32224, United States — Recruiting
Palm Beach Rheumatology and Wellness — Jupiter, Florida, 33458, United States — Recruiting
Arthritis & Rheumatology Center of South Florida — Margate, Florida, 33063, United States — Recruiting
Life Medical Research Group — Miami Gardens, Florida, 33014, United States — Recruiting
Southwest Florida Rheumatology — Riverview, Florida, 33569, United States — Recruiting
Southeast Georgia Physician Associates-Rheumatology — Brunswick, Georgia, 31520, United States — Recruiting
Indiana University Health — Carmel, Indiana, 46280, United States — Recruiting
Johns Hopkins University — Baltimore, Maryland, 21224, United States — Recruiting
Tufts University — Boston, Massachusetts, 02111, United States — Recruiting
University of Massachusetts Chan Medical School — Worcester, Massachusetts, 01655, United States — Recruiting

Study details

Start date: September 22, 2021
Primary completion date: May 31, 2029
Completion date: July 31, 2029
First posted: December 31, 2020
Collaborators: Patient-Centered Outcomes Research Institute

Source and update information

Source: ClinicalTrials.gov
NCT ID: NCT04692493
Registry last updated: September 24, 2026
QualifiedStudies registry data refreshed: October 2, 2026
QualifiedStudies record fetched: October 2, 2026

View NCT04692493 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

About joining clinical research

Find clinical trials you may match with

QualifiedStudies can help you search for research opportunities related to your health. Availability of this specific study through QualifiedStudies has not been established.

Find clinical trials you may match with | Clinical trial FAQ