fMRI and IVCM Cornea Microscopy of CXL in Keratoconus

NCT ID
NCT04439552
Registry status
Recruiting
Study type
Observational
Sponsor
Boston Children's Hospital
Conditions
Cornea, Cornea Injury, Keratoconus, Pain, Acute, Pain, Chronic, Pain, Postoperative, Surgical Injury, Surgical Wound

Overview

ClinicalTrials.gov lists this study as Recruiting.

Official title: Neuroplasticity of Pain Pathways and Corneal Afferent Regeneration Following Corneal Crosslinking (CXL) in Keratoconus

Enrollment: 60 participants (Estimated).

What is being studied

No interventions are listed in the registry data.

Who may be eligible

Ages
8 Years to 35 Years
Sex
All
Healthy volunteers accepted
Yes

ClinicalTrials.gov lists the following eligibility criteria.

Inclusion Criteria: CXL Group * Age 8-35 years * Clinical diagnosis of keratoconus and seeking CXL treatment * English speaking ability sufficient to comprehend consent with parental assistance * MRI compatible * Ability to lie still for an MRI session (60 minutes) Control Group * Age 8-35 years * No diagnosis of keratoconus * English speaking ability sufficient to comprehend consent with parental assistance * MRI compatible * Ability to lie still for an MRI session (60 minutes) Exclusion Criteria (Both Groups): * Claustrophobic * Weight \> 285 lbs (weight limit of the MRI table) * Significant medical history, including: Current DSM-IV-TR axis I psychiatric disorders. Chronic pain Significant head injury Seizures Brain tumor Cerebrovascular accident Neurological disease aside from migraine HIV-AIDs Prescription medication strongly implicated in causing dry eyes * Magnetic implants or metal-containing tattoos on their chest or above * Pregnancy * History of contact lens wear * Any allergic response to a numbing eyedrop in the past

Study locations

1 study location is listed.

Recruiting site status is explicitly provided for 1 location; 1 is listed as Recruiting.

Countries: United States

  • Massachusetts, United States: 1

Sample of listed locations

  • Boston Children's Hospital — Boston, Massachusetts, 02115, United States — Recruiting

Study details

Start date
October 4, 2021
Primary completion date
August 1, 2027
Completion date
December 1, 2027
First posted
June 19, 2020

Source and update information

Source
ClinicalTrials.gov
NCT ID
NCT04439552
Registry last updated
December 19, 2025
QualifiedStudies registry data refreshed
October 2, 2026
QualifiedStudies record fetched
October 2, 2026

View NCT04439552 on ClinicalTrials.gov

Trial information can change. Confirm current study details with the study team or the registry.

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